感染性角膜炎在纽约西部:10年回顾患者人口统计,临床管理和治疗失败。

Frontiers in ophthalmology Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.3389/fopht.2024.1469966
Caroline Maretz, Jason Atlas, Shalini Shah, Michael B Sohn, Rachel A F Wozniak
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引用次数: 0

摘要

背景:感染性角膜炎(IK)是一种致盲性疾病,也是眼部疾病的重要原因。了解IK的区域趋势对于了解该病的流行病学和临床结果非常重要。方法:回顾性分析10年患者的社会人口学因素、病史、眼史、临床过程和结果。本研究特别关注这些特征,因为它与IK治疗失败有关,定义为需要超过2周的愈合或手术干预,收集微生物培养物的可能性,手术干预,并表现出疾病的严重程度。结果:在罗切斯特大学共发现935例IK。年龄(p=0.004),既往角膜移植史(p=0.009),出现时严重视力丧失(p)结论:本研究确定了罗切斯特大学10年来IK患者的患者特征和临床病程,为患者人群的区域趋势以及临床结果提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Infectious keratitis in Western New York: a 10-year review of patient demographics, clinical management, and treatment failure.

Background: Infectious keratitis (IK) is a blinding disease and an important cause of ocular morbidity. Understanding regional trends in IK are important to understand the epidemiology and clinical outcomes of this disease.

Methods: In this 10-year retrospective review, patient characteristics including sociodemographic factors, medical history, and ocular history were collected as well as the clinical course and outcomes. This study particularly focused on these characteristics as it relates to treatment failure in IK, as defined as requiring more than 2 weeks to heal or surgical intervention, likelihood of having microbiology cultures collected, surgical intervention, and presenting disease severity.

Results: 935 cases of IK were identified at the University of Rochester. Age (p=0.004), history of prior corneal transplant (p=0.009), severe vision loss on presentation (p<0.001), large ulcer size (p=0.001), and fungal (p=0.001) or protozoan (p=0.009) infections were all significantly associated with treatment failure. Both ulcer size (p<0.001) and severity of vision loss (p<0.001) were associated with a higher likelihood of having microbiology cultures as well as surgical intervention. Patients' whose home address was greater than 60 miles from the University were also more likely to present with a more severe ulcer (p<0.001) and undergo a surgical intervention (p=0.05). In studying the impact of race and ethnicity, Black patients were less likely to receive corneal cultures compared to White patients (p=0.02).

Conclusions: This study defined the patient characteristics and clinical course of patients with IK over 10 years at the University of Rochester providing insight into regional trends of the patient population as well as clinical outcomes.

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