长期COVID患者集中微选择治疗后病假、疲劳和功能状态的持续改善：一项为期1年的前瞻性非对照研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychores.2024.112023

Bente Frisk , Marte Jürgensen , Birgitte Espehaug , Eirik Søfteland , Gerd Kvale

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引用次数: 0

摘要

背景：新冠肺炎疫情已影响到全球约2亿人，对个人、卫生保健系统和社会产生了重大影响。治疗指南缺乏关于增加活动的明确建议。本研究旨在评估患者满意度、疾病感知和患者激活的主要结局。此外，对长期感染COVID的患者进行集中微选择干预后，从基线到12个月随访期间，功能水平、病假、疲劳、呼吸困难和运动能力的潜在变化。方法：本前瞻性干预性研究于2021年5月26日开始，随访12个月，纳入78例长冠患者，年龄19-67岁，平均年龄40.3±12.0岁。干预分为三个同等重要的阶段：治疗前准备，为期3天的集中微选择干预，以及将改变融入日常生活。结果：随访3个月和12个月，分别有71例（91%）和65例（83%）患者完成问卷调查和体格检查。患者报告疾病感知和健康激活显著增强。病假从基线时的63%显著下降到3个月和12个月时的43%和23% (p结论：基于微选择的干预对长期COVID患者是安全的，非常令人满意的，显著增强了健康激活，同时功能水平和疲劳的快速改善在随访一年中持续改善，病假也显著减少。

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Sustained improvements in sick leave, fatigue and functional status following a concentrated micro-choice based treatment for patients with long COVID: A 1 year prospective uncontrolled study

Background

Long COVID has affected approximately 200 million people globally, with substantial consequences for the individuals, healthcare systems and society. Treatment guidelines lack clear recommendations regarding increased activity. This study aimed to evaluate primary outcomes as patients' satisfaction, illness perception and patient activation. In addition, potential changes in functional levels, sick leave, fatigue, dyspnea, and exercise capacity from baseline to 12-month follow-up after a concentrated micro-choice-based intervention in patients with long COVID.

Methods

This prospective interventional study, study start 26 May 2021, with 12-month follow-up included 78 patients with long COVID aged 19–67 years, mean age 40.3 ± 12.0 years. The intervention was structured into three equally important phases: pre-treatment preparation, a 3-day concentrated micro-choice-based intervention and integrating the changes into everyday living.

Results

At 3 and 12-month follow-ups, 71 (91 %) and 65 (83 %) patients, respectively completed questionnaires and physical tests. The patients reported significant enhancements in illness perception and health activation. Sick leave decreased significantly from 63 % at baseline to 43 % and 23 % at 3 and 12-month, respectively (p < 0.001). Fatigue decreased significantly at 3-month (mean difference (MD) = −5.5, 95 % CI: −6.6 to −4.3) and at 12-month (MD = −7.0, CI: −8.3 to −5.7). Functional level and exercise capacity increased (p < 0.001), and dyspnea decreased (p < 0.001), at both follow-ups regardless of baseline fatigue severity.

Conclusion

The micro-choice-based intervention for patients with long COVID was safe, highly satisfactory and significantly enhanced health activation alongside rapid improvements in functional levels and fatigue which continued improving throughout the follow-up year, together with significant reduction in sick leave.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.