Eunwoo Kim, Ah Young Leem, Ji Ye Jung, Young Sam Kim, Youngmok Park
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With an increase in MF ratio of 1, in men, the FVC increased by 43.9 mL, FEV<sub>1</sub> by 37.6 mL, and FEV<sub>1</sub>/FVC by 0.320%, while in non-smoking women, the FVC increased by 55.8 mL, FEV<sub>1</sub> by 44.3 mL, and FEV<sub>1</sub>/FVC by 0.265% (all P < 0.001). The MF ratio-decreased group showed further annual deterioration in lung function than the MF ratio-increased group (men: FVC - 44.1 mL vs. -28.4 mL, FEV<sub>1</sub> -55.8 mL vs. -39.7 mL, FEV<sub>1</sub>/FVC - 0.53% vs. -0.42%; non-smoking women: FVC - 34.2 mL vs. -30.3 mL, FEV<sub>1</sub> -38.0 mL vs. -35.2 mL; all P < 0.001, except FEV<sub>1</sub> in non-smoking women; P = 0.005). The odds ratio for the incidence of airflow obstruction according to the MF ratio was 0.77 (95% CI, 0.68-0.87) in men and 0.85 (95% CI, 0.74-0.97) in non-smoking women.</p><p><strong>Conclusions: </strong>Long-term changes in the MF ratio are related to lung function deterioration and incidence of airflow obstruction in middle-aged general population.</p>","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"25 1","pages":"444"},"PeriodicalIF":5.8000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673890/pdf/","citationCount":"0","resultStr":"{\"title\":\"Changes in muscle-to-fat ratio are associated with lung function decline and airflow obstruction in the general population.\",\"authors\":\"Eunwoo Kim, Ah Young Leem, Ji Ye Jung, Young Sam Kim, Youngmok Park\",\"doi\":\"10.1186/s12931-024-03081-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The long-term relationship between body composition and lung function has not yet been fully demonstrated. We investigated the longitudinal association between muscle-to-fat (MF) ratio and lung function among middle-aged general population.</p><p><strong>Methods: </strong>Participants were enrolled from a community-based prospective cohort between 2005 and 2014. Lung function parameters (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV<sub>1</sub>], and FEV<sub>1</sub>/FVC) and the MF ratio (total body muscle mass [kg]/fat mass [kg]) were assessed biannually via spirometry and bioelectrical impedance analysis, respectively.</p><p><strong>Results: </strong>We followed up 4,712 participants (age 53.9 ± 7.9 years, men 45.8%) for 8 years. With an increase in MF ratio of 1, in men, the FVC increased by 43.9 mL, FEV<sub>1</sub> by 37.6 mL, and FEV<sub>1</sub>/FVC by 0.320%, while in non-smoking women, the FVC increased by 55.8 mL, FEV<sub>1</sub> by 44.3 mL, and FEV<sub>1</sub>/FVC by 0.265% (all P < 0.001). The MF ratio-decreased group showed further annual deterioration in lung function than the MF ratio-increased group (men: FVC - 44.1 mL vs. -28.4 mL, FEV<sub>1</sub> -55.8 mL vs. -39.7 mL, FEV<sub>1</sub>/FVC - 0.53% vs. -0.42%; non-smoking women: FVC - 34.2 mL vs. -30.3 mL, FEV<sub>1</sub> -38.0 mL vs. -35.2 mL; all P < 0.001, except FEV<sub>1</sub> in non-smoking women; P = 0.005). 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引用次数: 0
摘要
背景：身体成分与肺功能之间的长期关系尚未得到充分证实。我们调查了中年人群中肌脂比（MF）与肺功能之间的纵向关系。方法：从2005年至2014年的社区前瞻性队列中招募参与者。肺功能参数（用力肺活量[FVC]、1 s内用力呼气量[FEV1]和FEV1/FVC）和MF比值（全身肌肉质量[kg]/脂肪质量[kg]）分别通过肺活量测定法和生物电阻抗分析每半年评估一次。结果：随访8年，共4712例（年龄53.9±7.9岁，男性45.8%）。当MF比增加1时，男性FVC增加43.9 mL， FEV1增加37.6 mL， FEV1/FVC增加0.20%，而非吸烟女性FVC增加55.8 mL， FEV1增加44.3 mL， FEV1/FVC增加0.265% (P均为-55.8 mL比-39.7 mL, FEV1/FVC - 0.53%比-0.42%；非吸烟女性：FVC - 34.2 mL vs -30.3 mL, FEV1 -38.0 mL vs -35.2 mL；所有非吸烟女性的p1；p = 0.005)。根据MF比，男性发生气流阻塞的优势比为0.77 (95% CI, 0.68-0.87)，非吸烟女性为0.85 （95% CI, 0.74-0.97）。结论：中老年普通人群肺功能恶化和气流阻塞发生率与MF比值的长期变化有关。
Changes in muscle-to-fat ratio are associated with lung function decline and airflow obstruction in the general population.
Background: The long-term relationship between body composition and lung function has not yet been fully demonstrated. We investigated the longitudinal association between muscle-to-fat (MF) ratio and lung function among middle-aged general population.
Methods: Participants were enrolled from a community-based prospective cohort between 2005 and 2014. Lung function parameters (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV1], and FEV1/FVC) and the MF ratio (total body muscle mass [kg]/fat mass [kg]) were assessed biannually via spirometry and bioelectrical impedance analysis, respectively.
Results: We followed up 4,712 participants (age 53.9 ± 7.9 years, men 45.8%) for 8 years. With an increase in MF ratio of 1, in men, the FVC increased by 43.9 mL, FEV1 by 37.6 mL, and FEV1/FVC by 0.320%, while in non-smoking women, the FVC increased by 55.8 mL, FEV1 by 44.3 mL, and FEV1/FVC by 0.265% (all P < 0.001). The MF ratio-decreased group showed further annual deterioration in lung function than the MF ratio-increased group (men: FVC - 44.1 mL vs. -28.4 mL, FEV1 -55.8 mL vs. -39.7 mL, FEV1/FVC - 0.53% vs. -0.42%; non-smoking women: FVC - 34.2 mL vs. -30.3 mL, FEV1 -38.0 mL vs. -35.2 mL; all P < 0.001, except FEV1 in non-smoking women; P = 0.005). The odds ratio for the incidence of airflow obstruction according to the MF ratio was 0.77 (95% CI, 0.68-0.87) in men and 0.85 (95% CI, 0.74-0.97) in non-smoking women.
Conclusions: Long-term changes in the MF ratio are related to lung function deterioration and incidence of airflow obstruction in middle-aged general population.
期刊介绍：
Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases.
As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion.
Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.
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