[尼武单抗治疗不能切除的晚期胃癌病理完全缓解1例]。

Q4 Medicine

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-12-01

Rei Ogura, Kazuhiro Migita, Ayumi Nishioka, Yusuke Komeda, Tadashi Nakagawa, Takashi Inoue, Yasuyuki Nakata, Takahiro Yoshikawa, Naoki Kamitani, Daiki Nezu, Hiromi Kanai, Tomohiro Kubo, Manabu Matsushita, Hideki Matsuo, Kei Moriya, Saiho Ko

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引用次数: 0

摘要

一名70岁男子因胃脘痛被当地医院收治，诊断为2型胃癌。CT增强扫描显示肝脏S3、S8转移灶，肿瘤分类为cT4aN2H1型，cStageⅣB。在S-1 +奥沙利铂和ramucirumab治疗失败后开始纳武单抗单药治疗。6个疗程后，原发肿瘤、淋巴结、肝转移灶均明显缩小。患者行胃近端切除术、D2淋巴结清扫和部分肝切除术。组织病理学检查未见肿瘤细胞残留，组织学反应为3级。

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本刊更多论文

[A Case of Pathological Complete Response after Nivolumab Therapy in Unresectable Advanced Gastric Cancer].

A 70-year-old man was admitted to a local hospital with epigastric pain and diagnosed with type-2 gastric cancer. Contrast-enhanced CT scan showed metastases in S3 and S8 of the liver, and the tumor was classified as type cT4aN2H1, cStage ⅣB. Nivolumab monotherapy was initiated after failure of treatment with S-1 plus oxaliplatin and ramucirumab. After 6 courses, the primary tumor, lymph nodes, and liver metastases had shrunk to a remarkable degree. The patient underwent a proximal gastrectomy with D2 lymph node dissection and partial liver resection. Histopathological examination revealed no remaining tumor cells, with a histological response Grade 3.

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来源期刊

Japanese Journal of Cancer and Chemotherapy Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

337