他克莫司诱发的血栓性微血管病（TMA）在心肺移植后用eculizumab成功治疗。

IF 1.6 4区医学 Q4 IMMUNOLOGY

Transplant immunology Pub Date : 2024-12-26 DOI:10.1016/j.trim.2024.102169

Zein Kattih, Aldo Iacono, Christina Saikus, Michael Esposito, Zachary Kon, Maksim Korotun

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引用次数: 0

摘要

他克莫司诱发的血栓性微血管病（TMA）引起的无系统性特征的急性肾损伤（AKI）是一种罕见的疾病，特别是在非肾实体器官移植后。病例报告：我们描述了一例合并心肺移植后AKI的患者。肾活检显示急性血栓性微血管病变，最终促使启动eculizumab，一种针对补体C5的单克隆抗体，随后肾功能恢复。结果/结论：本病例突出了肾分离性药物性TMA是心肺移植后AKI的罕见病因。我们强调在指导管理策略中进行肾活检的重要性。

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Tacrolimus-induced thrombotic microangiopathy (TMA) after heart and lung transplantation successfully treated with eculizumab.

Introduction: Tacrolimus-induced thrombotic microangiopathy (TMA) causing acute kidney injury (AKI) without systemic features is a rare entity, particularly after non-renal solid organ transplantation.

Case report: We describe the case of a patient with AKI after combined heart and lung transplantation. Renal biopsy revealed acute thrombotic microangiopathy which ultimately prompted initiation of eculizumab, a monoclonal antibody targeted against complement C5, with subsequent recovery in renal function.

Results/conclusion: This case highlights renal isolated drug-induced TMA as a rarely reported cause of AKI post heart-lung transplantation. We emphasize the importance of performing a renal biopsy in guiding management strategies.

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来源期刊

Transplant immunology 医学-免疫学

CiteScore

2.10

自引率

13.30%

发文量

198

审稿时长

48 days

期刊介绍： Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.