{"title":"双加氧酶TET1的表观遗传调控研究进展","authors":"Ling Xu, Zhongkun Cheng, Jingxian Zhao, Yanyan Liu, Yongju Zhao, Xiaowei Yang","doi":"10.13345/j.cjb.240191","DOIUrl":null,"url":null,"abstract":"<p><p>Ten-eleven translocation 1 (TET1) protein is an alpha-ketoglutaric acid (α-KG) and Fe<sup>2+</sup>-dependent dioxygenase. It plays a role in the active demethylation of DNA by hydroxylation of 5-methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (5-hmC). Ten-eleven translocation 1 (TET1) protein is involved in maintaining genome methylation homeostasis and epigenetic regulation. Abnormally expressed TET1 and 5-mC oxidative derivatives have become potential markers in various biological and pathological processes and a research focus in the fields of embryonic development and malignant tumors. This paper introduces the structure and demethylation mechanism of TET1, reviews the research status of epigenetic regulation by TET1 in embryonic development, immune responses, stem cell regulation, cancer progression, and nervous system development, and briefs the upstream regulatory mechanism of TET1, hoping to provide new inspirations for further research in related fields.</p>","PeriodicalId":21778,"journal":{"name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","volume":"40 12","pages":"4351-4364"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Advances in epigenetic regulation of the dioxygenase TET1].\",\"authors\":\"Ling Xu, Zhongkun Cheng, Jingxian Zhao, Yanyan Liu, Yongju Zhao, Xiaowei Yang\",\"doi\":\"10.13345/j.cjb.240191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ten-eleven translocation 1 (TET1) protein is an alpha-ketoglutaric acid (α-KG) and Fe<sup>2+</sup>-dependent dioxygenase. It plays a role in the active demethylation of DNA by hydroxylation of 5-methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (5-hmC). Ten-eleven translocation 1 (TET1) protein is involved in maintaining genome methylation homeostasis and epigenetic regulation. Abnormally expressed TET1 and 5-mC oxidative derivatives have become potential markers in various biological and pathological processes and a research focus in the fields of embryonic development and malignant tumors. This paper introduces the structure and demethylation mechanism of TET1, reviews the research status of epigenetic regulation by TET1 in embryonic development, immune responses, stem cell regulation, cancer progression, and nervous system development, and briefs the upstream regulatory mechanism of TET1, hoping to provide new inspirations for further research in related fields.</p>\",\"PeriodicalId\":21778,\"journal\":{\"name\":\"Sheng wu gong cheng xue bao = Chinese journal of biotechnology\",\"volume\":\"40 12\",\"pages\":\"4351-4364\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sheng wu gong cheng xue bao = Chinese journal of biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13345/j.cjb.240191\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13345/j.cjb.240191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
ten - 11易位1 （TET1）蛋白是α-酮戊二酸（α-KG）和Fe2+依赖的双加氧酶。它通过将5-甲基胞嘧啶（5-mC）羟基化为5-羟甲基胞嘧啶（5-hmC），在DNA的活性去甲基化中起作用。10 - 11易位1 （TET1）蛋白参与维持基因组甲基化稳态和表观遗传调控。异常表达的TET1和5-mC氧化衍生物已成为各种生物学和病理过程的潜在标记物，是胚胎发育和恶性肿瘤领域的研究热点。本文介绍了TET1的结构和去甲基化机制，综述了TET1在胚胎发育、免疫应答、干细胞调控、肿瘤进展、神经系统发育等方面的表观遗传调控研究现状，并简要介绍了TET1的上游调控机制，希望为相关领域的进一步研究提供新的启示。
[Advances in epigenetic regulation of the dioxygenase TET1].
Ten-eleven translocation 1 (TET1) protein is an alpha-ketoglutaric acid (α-KG) and Fe2+-dependent dioxygenase. It plays a role in the active demethylation of DNA by hydroxylation of 5-methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (5-hmC). Ten-eleven translocation 1 (TET1) protein is involved in maintaining genome methylation homeostasis and epigenetic regulation. Abnormally expressed TET1 and 5-mC oxidative derivatives have become potential markers in various biological and pathological processes and a research focus in the fields of embryonic development and malignant tumors. This paper introduces the structure and demethylation mechanism of TET1, reviews the research status of epigenetic regulation by TET1 in embryonic development, immune responses, stem cell regulation, cancer progression, and nervous system development, and briefs the upstream regulatory mechanism of TET1, hoping to provide new inspirations for further research in related fields.
期刊介绍：
Chinese Journal of Biotechnology (Chinese edition) , sponsored by the Institute of Microbiology, Chinese Academy of Sciences and the Chinese Society for Microbiology, is a peer-reviewed international journal. The journal is cited by many scientific databases , such as Chemical Abstract (CA), Biology Abstract (BA), MEDLINE, Russian Digest , Chinese Scientific Citation Index (CSCI), Chinese Journal Citation Report (CJCR), and Chinese Academic Journal (CD version). The Journal publishes new discoveries, techniques and developments in genetic engineering, cell engineering, enzyme engineering, biochemical engineering, tissue engineering, bioinformatics, biochips and other fields of biotechnology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
