{"title":"早期精神分裂症的自闭症特征严重程度：在主观生活质量和社会功能中的作用。","authors":"Ayumu Wada, Risa Yamada, Yuji Yamada, Chika Sumiyoshi, Ryota Hashimoto, Junya Matsumoto, Akiko Kikuchi, Ryotaro Kubota, Makoto Matsui, Kana Nakachi, Chinatsu Fujimaki, Leona Adachi, Andrew Stickley, Naoki Yoshimura, Tomiki Sumiyoshi","doi":"10.1016/j.schres.2024.12.003","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is a cardinal feature in patients with schizophrenia and leads to poor social functioning. Recently, the treatment of schizophrenia has evolved to include the goal of improving quality of life (QoL). However, most of the factors influencing subjective QoL are unknown. Autistic traits have been shown to co-occur with various psychiatric conditions including schizophrenia. Hence, the present study aimed to investigate whether cognitive function and autistic trait severity are associated with social functioning and subjective QoL in patients with early schizophrenia.</p><p><strong>Methods: </strong>Data were analyzed from 183 outpatients diagnosed with early schizophrenia in Tokyo, Japan. Information was obtained on neurocognition with the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Autistic trait severity was assessed using the Autism Spectrum Quotient (AQ), while social functioning was measured with the Specific Levels of Functioning Scale Japanese version. Information was obtained on subjective QoL with the Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version. Multiple regression analysis was used to examined associations.</p><p><strong>Results: </strong>In an analysis adjusted for demographic characteristics (age, sex and education), both autistic trait severity (β = -0.56, p < 0.01) and neurocognitive function (β = 4.37, p < 0.01) were significantly associated with social function. On the other hand, only autistic trait severity made a significant contribution to the prediction of subjective QoL (β = -1.79, p < 0.01).</p><p><strong>Conclusions: </strong>The results of this study suggest that efforts to detect and treat cognitive impairment and comorbid autistic trait in early schizophrenia may be important for improving social functioning and subjective QoL in this population. In particular intervention that targets autistic trait severity seems to be key to achieving personal recovery in patients with schizophrenia.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"131-136"},"PeriodicalIF":3.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Autistic trait severity in early schizophrenia: Role in subjective quality of life and social functioning.\",\"authors\":\"Ayumu Wada, Risa Yamada, Yuji Yamada, Chika Sumiyoshi, Ryota Hashimoto, Junya Matsumoto, Akiko Kikuchi, Ryotaro Kubota, Makoto Matsui, Kana Nakachi, Chinatsu Fujimaki, Leona Adachi, Andrew Stickley, Naoki Yoshimura, Tomiki Sumiyoshi\",\"doi\":\"10.1016/j.schres.2024.12.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cognitive impairment is a cardinal feature in patients with schizophrenia and leads to poor social functioning. Recently, the treatment of schizophrenia has evolved to include the goal of improving quality of life (QoL). However, most of the factors influencing subjective QoL are unknown. Autistic traits have been shown to co-occur with various psychiatric conditions including schizophrenia. Hence, the present study aimed to investigate whether cognitive function and autistic trait severity are associated with social functioning and subjective QoL in patients with early schizophrenia.</p><p><strong>Methods: </strong>Data were analyzed from 183 outpatients diagnosed with early schizophrenia in Tokyo, Japan. Information was obtained on neurocognition with the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Autistic trait severity was assessed using the Autism Spectrum Quotient (AQ), while social functioning was measured with the Specific Levels of Functioning Scale Japanese version. Information was obtained on subjective QoL with the Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version. Multiple regression analysis was used to examined associations.</p><p><strong>Results: </strong>In an analysis adjusted for demographic characteristics (age, sex and education), both autistic trait severity (β = -0.56, p < 0.01) and neurocognitive function (β = 4.37, p < 0.01) were significantly associated with social function. On the other hand, only autistic trait severity made a significant contribution to the prediction of subjective QoL (β = -1.79, p < 0.01).</p><p><strong>Conclusions: </strong>The results of this study suggest that efforts to detect and treat cognitive impairment and comorbid autistic trait in early schizophrenia may be important for improving social functioning and subjective QoL in this population. 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引用次数: 0
摘要
背景：认知障碍是精神分裂症患者的主要特征，导致社会功能低下。最近，精神分裂症的治疗已经发展到包括提高生活质量（QoL）的目标。然而，大多数影响主观生活质量的因素是未知的。自闭症特征已被证明与包括精神分裂症在内的各种精神疾病共同发生。因此，本研究旨在探讨认知功能和自闭症特征严重程度是否与早期精神分裂症患者的社会功能和主观生活质量相关。方法：对日本东京183例早期精神分裂症门诊患者的资料进行分析。通过日文版《精神分裂症患者认知能力简要评估》获得神经认知方面的信息。自闭症特征的严重程度是用自闭症谱系商（AQ）来评估的，而社会功能是用日本版的特定功能水平量表来衡量的。获得抗精神病药物治疗后主观生活质量与主观幸福感的关系。采用多元回归分析检验相关性。结果：在人口统计学特征（年龄、性别和教育程度）调整后的分析中，自闭症特征严重程度（β = -0.56, p < 0.01）和神经认知功能（β = 4.37, p < 0.01）与社会功能显著相关。另一方面，只有自闭症特质严重程度对主观生活质量的预测有显著贡献（β = -1.79, p < 0.01）。结论：本研究结果表明，努力检测和治疗早期精神分裂症患者的认知障碍和共病自闭症特征可能对改善这一人群的社会功能和主观生活质量很重要。特别是针对自闭症特征严重程度的干预似乎是实现精神分裂症患者个人康复的关键。
Autistic trait severity in early schizophrenia: Role in subjective quality of life and social functioning.
Background: Cognitive impairment is a cardinal feature in patients with schizophrenia and leads to poor social functioning. Recently, the treatment of schizophrenia has evolved to include the goal of improving quality of life (QoL). However, most of the factors influencing subjective QoL are unknown. Autistic traits have been shown to co-occur with various psychiatric conditions including schizophrenia. Hence, the present study aimed to investigate whether cognitive function and autistic trait severity are associated with social functioning and subjective QoL in patients with early schizophrenia.
Methods: Data were analyzed from 183 outpatients diagnosed with early schizophrenia in Tokyo, Japan. Information was obtained on neurocognition with the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Autistic trait severity was assessed using the Autism Spectrum Quotient (AQ), while social functioning was measured with the Specific Levels of Functioning Scale Japanese version. Information was obtained on subjective QoL with the Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version. Multiple regression analysis was used to examined associations.
Results: In an analysis adjusted for demographic characteristics (age, sex and education), both autistic trait severity (β = -0.56, p < 0.01) and neurocognitive function (β = 4.37, p < 0.01) were significantly associated with social function. On the other hand, only autistic trait severity made a significant contribution to the prediction of subjective QoL (β = -1.79, p < 0.01).
Conclusions: The results of this study suggest that efforts to detect and treat cognitive impairment and comorbid autistic trait in early schizophrenia may be important for improving social functioning and subjective QoL in this population. In particular intervention that targets autistic trait severity seems to be key to achieving personal recovery in patients with schizophrenia.
期刊介绍：
As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership!
Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue.
The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.
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