清理切尔诺贝利事故后果参与者和从冠状病毒病(covid-19)中康复的乌克兰国防军军事人员的电生理变化。

D A Bazyka, K V Kuts, I V Perchuk, G Y Kreinis, K Y Antipchuk, Z L Vasylenko, M S Hryhorenko
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引用次数: 0

摘要

目的:对切尔诺贝利清理工人和乌克兰武装部队(AFU)既往冠状病毒病(COVID-19)军人及对照组个体进行临床和神经生理学研究,研究电离辐射、心理情绪应激和既往冠状病毒感染对脑功能的长期影响。材料与方法:对切尔诺贝利清理工人和乌克兰武装部队(AFU)感染冠状病毒病(COVID-19)的军人及对照组个体进行前瞻性临床研究。主要群体——30名男性(切尔诺贝利清理工人)参与清理切尔诺贝利核电站(ChNPP)事故造成的后果,此前已证实患有COVID-19。作为疾病控制组(NCG),研究人员在2020-2022年期间对24名确诊为慢性脑血管疾病(CVD)、未暴露于放射源、战争相关心理情绪压力和COVID-19的男性进行了检查。根据COVID-19的历史,AFU服务人员被分为两个亚组:“COVID+”和“COVID-”。根据ICD-10确定神经精神障碍的诊断。视觉和频谱脑电图分析评估了被动清醒(rsEEG)时的大脑功能。结果:除“COVID+”组有较高的器质性人格障碍(F07)外,“COVID+”组与NCG组在临床神经精神特征上无显著差异(p < 0.001)。在切尔诺贝利清洁工人组中,与NCG相比,“COVID+”脑电图相对(%)频谱δ功率显著弥漫性增加,左侧颞后区绝对频谱δ功率显著增加(p < 0.05)。与AFU“COVID-”组相比,AFU“COVID+”组的相对波谱功率显著弥漫性增加,双侧顶叶区过度(p < 0.05 - 0.01),双侧额区绝对波谱功率显著增加(p < 0.05)。结论:与患有慢性心血管疾病的对照组相比,首次在COVID-19康复的切尔诺贝利清理工人中检测到脑生物电活动向δ频率的明显弥漫性减慢。既往感染COVID-19的AFU军人存在中度持续性脑功能障碍。这些变化需要进一步的观察和研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ELECTROPHYSIOLOGICAL CHANGES IN THE PARTICIPANTS OF THE LIQUIDATION OF THE CONSEQUENCES OF THE CHORNOBYL ACCIDENT AND THE MILITARY PERSONNEL OF THE UKRAINIAN DEFENSE FORCES RECOVERING FROM CORONAVIRUS DISEASE (COVID-19).

Objective: to conduct a clinical and neurophysiological study of Chornobyl clean-up workers and military personnelof the Armed Forces of Ukraine (AFU) with previous coronavirus disease (COVID-19) and individuals of the comparison groups to study the impact of long-term effects of ionizing radiation, psychoemotional stress and previouscoronavirus infection on cerebral functioning.

Materials and methods: A prospective clinical study of Chornobyl clean-up workers and servicemen of the ArmedForces of Ukraine (AFU) who had coronavirus disease (COVID-19) and individuals of the comparison groups. Themain group - 30 males participated in liquidating the consequences of the Chornobyl Nuclear Power Plant (ChNPP)accident with previously verified COVID-19 (Chornobyl clean-up workers). As a nosological control group (NCG), 24men with verified chronic cerebrovascular disorder (CVD) not exposed to radiation sources, war-associated psychoemotional stress, and COVID-19 were examined in 2020-2022. Depending on the history of COVID-19, the AFU servicemen were divided into 2 subgroups: «COVID+» and «COVID-». The diagnosis of neuropsychiatric disorders wasestablished according to ICD-10. Visual and spectral EEG analyses assessed cerebral functions in passive wakefulness (rsEEG).

Results: Chornobyl clean-up workers «COVID+» and NCG groups did not differ significantly in clinical neuropsychiatric features, except for a higher frequency of organic personality disorder (F07) in the group of the Chornobyl cleanworkers «COVID+» (p < 0.001). In the group of the Chornobyl clean workers «COVID+» relative ( %) spectral deltapower of EEG was significantly diffusely increased as well as absolute spectral delta-power in the left posterior-temporal area compared to NCG (p < 0.05). A significant diffuse increase in relative spectral theta-power with a bilateral excess in parietal areas (p < 0.05 - 0.01), as well as a significant increase in absolute spectral theta-power bilaterally in frontal areas (p < 0.05) was found in the group AFU «COVID+», compared to the group AFU «COVID-».

Conclusions: For the first time, a pronounced diffuse slowing of cerebral bioelectrical activity to delta-frequencieswas detected in the Chornobyl clean-up workers being COVID-19 recuperates compared to the comparison groupwith chronic CVD. The AFU servicemen with previous COVID-19 have moderate persistent cerebral dysfunction. Thesechanges require further observation and study.

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Problemy radiatsiinoi medytsyny ta radiobiolohii
Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging
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