TR53和电离辐射：在急性髓性白血病发病机制和预后中的作用（文献回顾）。

Problemy radiatsiinoi medytsyny ta radiobiolohii Pub Date : 2024-12-01 DOI:10.33145/2304-8336-2024-29-67-78

T F Liubarets

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引用次数: 0

摘要

本文综述了ТР53基因和电离辐射（IR）在急性髓性白血病（AML）发病机制中的作用的文献资料。我们分析了ТР53在负面外部因素（IR，化疗药物）的影响下作为AML诱导启动子的功能的破坏。提出了AML分层的新方向，这将允许优化未来的治疗和延长这类患者的预期寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TR53 AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND PROGNOSIS OF THE COURSE OF ACUTE MYELOID LEUKEMIA (literature review).

The review presents literature data on the role of the ТР53 gene and ionizing radiation (IR) in the pathogenesis of acute myeloid leukemia (AML).The violation of ТР53 functioning as a promoter of AML induction under the influence of negative external factors (IR, chemotherapeutic agents) was analyzed. New directions of AML stratification are presented, which will allow to optimize the future therapy and extend the life expectancy of this category of patients.

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来源期刊

Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.60

自引率

0.00%

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