雄性大鼠海马垂体腺苷酸环化酶激活多肽受体选择性拮抗剂的抗焦虑作用。

IF 2 Q3 NEUROSCIENCES
Kaito Sato, Shuichi Chiba, Taichi Hatakeyama, Takashi Matsuwaki, Gen Watanabe, Maiko Kawaguchi
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引用次数: 0

摘要

垂体腺苷酸环化酶激活多肽(PACAP)影响啮齿动物的压力相关行为,如焦虑样行为或恐惧条件反射。然而,先前的研究已经研究了脑室内注射这种pac1r选择性拮抗剂(PACAP-6-38)对焦虑样行为的影响,而不是海马注射。然而,有报道称,在恐惧条件反射测试中,向海马背侧施用PACAP-6-38可降低恐惧反应。因此,本研究旨在确定Sprague-Dawley大鼠海马背侧注射PACAP-6-38是否会影响升高+迷宫测试评估的焦虑样行为。结果,用PACAP-6-38治疗的大鼠比用生理盐水治疗的大鼠张开双臂的时间更长,这表明这种药物具有抗焦虑作用。综上所述,PACAP在海马背侧的作用可以促进焦虑样行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Administration of a Selective Antagonist for Pituitary Adenylate Cyclase-Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat.

Pituitary adenylate cyclase-activating polypeptide (PACAP) affects rodents' stress-related behaviors, such as anxiety-like behavior or fear conditioning. However, previous studies have investigated the effect of intracerebroventricular, but not hippocampal, injection of this PAC1R-selective antagonist (PACAP-6-38) on anxiety-like behavior. However, it has been reported that administration of PACAP-6-38 to the dorsal hippocampus reduces the fear response in a fear conditioning test. Therefore, this study aimed to determine whether the effect of dorsal hippocampal PACAP-6-38 injection in Sprague-Dawley rats can affect anxiety-like behavior assessed by an elevated plus-maze test. As a result, rats treated with PACAP-6-38 spent longer time in open arms than those with saline, suggesting that this drug has an anxiolytic effect. In conclusion, the role of PACAP in the dorsal hippocampus can promote anxiety-like behavior.

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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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