红树林真菌Talaromyces sp.三个新的二肽和两个新的聚酮衍生物：两个分离物质的抗氧化活性。

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-12-14 DOI:10.3390/md22120559

Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xuefeng Zhou

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引用次数: 0

摘要

从源自红树林沉积物的真菌Talaromyces sp. SCSIO 41431中分离到了5个新的代谢产物，包括3个环二肽衍生物（1-3）和2个聚酮衍生物（10-11），以及9个已知的代谢产物（4-9和12-15）。它们的结构是通过详细的核磁共振、质谱分析和量子化学计算确定的。描述了1的x射线单晶衍射分析。化合物13-15具有抗金黄色葡萄球菌活性，MIC值在25 ~ 50µg/mL之间。化合物9对大肠埃希菌、猪链球菌和红唇丹毒均有抑制作用，MIC值为100µg/mL。此外，化合物1和12具有清除DPPH自由基的活性，其EC50分别为27.62和29.34µg/mL，而阳性对照（抗坏血酸，EC50为12.74µg/mL）。

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Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances.

Five new metabolites, including three cyclic dipeptide derivatives (1-3) and two new polyketides (10-11), together with nine known ones (4-9 and 12-15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431. Their structures were determined using detailed NMR, MS spectroscopic analyses, and quantum chemical calculations. X-ray single-crystal diffraction analysis of 1 was described. Compounds 13-15 demonstrated activity against Staphylococcus aureus, with MIC values ranging from 25 to 50 µg/mL. Compound 9 showed activity against Escherichia coli, Streptococcus suis, and Erysipelothrix rhusiopathiae, with an MIC value of 100 µg/mL. In addition, compounds 1 and 12 showed DPPH radical scavenging activity, with the EC₅₀ of 27.62 and 29.34 µg/mL, compared to the positive control (ascorbic acid, EC₅₀, 12.74 µg/mL).

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.