溃疡性结肠炎伴急性心包炎一例美沙拉嗪剂量增加。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-26 DOI:10.2169/internalmedicine.4655-24

Jun Wada, Kazumasa Kawashima, Michio Onizawa, Naohiko Gunji, Yu Watahiki, Chiharu Sakuma, Mai Murakami, Tomoaki Mochimaru, Shunsuke Miura, Hiromasa Ohira

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引用次数: 0

摘要

美沙拉嗪引起的心包炎是罕见的，大多数病例发生在治疗开始时。一位患有溃疡性结肠炎的30岁男性患者在服用美沙拉嗪2000 mg/天治疗2年后复发。因此，美沙拉嗪的剂量增加到4000毫克。此后，便血改善，但出现前胸痛。胸片显示明显的心脏扩张（心胸比值63%），超声心动图显示心包积液。与美沙拉嗪相关的不良事件应仔细监测，不仅在治疗开始时，而且在剂量增加后。

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Ulcerative Colitis with Acute Pericarditis after Dose Escalation of Mesalazine.

Mesalazine-induced pericarditis is rare, and most cases occur at the time of treatment initiation. A 30-year-old man with ulcerative colitis who had experienced remission for 2 years with mesalazine 2,000 mg/day subsequently experienced relapse. Therefore, the mesalazine dose was increased to 4,000 mg. Thereafter, hematochezia improved, but anterior chest pain developed. Chest radiography revealed marked cardiac dilation (cardiothoracic ratio, 63%) and echocardiography revealed pericardial effusion. Adverse events associated with mesalazine should be carefully monitored, not only at the time of treatment initiation but also after dose escalation.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.