Ana De Los Ríos-Pérez, Alberto Federico García, Paula Gomez, Juan José Arias, Andrés Fandiño-Losada
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We also assessed survival outcomes to explore the model's potential utility across various clinical settings. These efforts align with quality improvement initiatives to reduce preventable mortality and supporting sustainable development goals.</p><p><strong>Methods: </strong>This retrospective cohort study included patients under 18 years of age who were treated at a hospital in Colombia between 2011 and 2019. New coefficients for TRISS covariates were calculated using logistic regression, with age treated as a continuous variable. Model performance was evaluated based on discrimination (C statistic) and calibration, comparing Peds-TRISS with the original TRISS. Internal validation was conducted using bootstrap resampling. Survival outcomes were assessed using the M and Z statistics, which are commonly used for international trauma outcome comparisons.</p><p><strong>Results: </strong>The study included 1,013 pediatric patients with a median age of 12 years (IQR 5-15), of whom 73% were male. The leading causes of injury were traffic accidents (31.1%), falls (28.8%), and assaults (28.7%). The overall mortality rate was 5.7%. The Peds-TRISS model demonstrated good calibration (HL = 9.7, <i>p</i> = 0.3) and discrimination (C statistic = 0.98, 95% CI 0.97-0.99), with no statistically significant difference in the ROC curve comparison with the original TRISS. Internal validation demonstrated strong performance of Peds-TRISS. The M and <i>Z</i> statistics were 0.93 and 0, respectively, indicating no significant differences between expected and observed survival rates.</p><p><strong>Conclusions: </strong>Most fatalities occurred among adolescents and were due to intentional injuries. The Peds-TRISS model showed a partial improvement in performance compared to the original TRISS, with superior results in terms of calibration, although not in discrimination. These findings highlight the potential of model customization for specific populations. 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引用次数: 0
摘要
背景:儿童创伤是一个主要的全球健康问题,占5岁以上死亡和疾病负担的很大比例。有效的分诊和管理在儿童创伤护理中至关重要,创伤损伤严重程度评分(TRISS)等预测模型在估计生存概率和指导质量提高方面发挥着至关重要的作用。然而,TRISS没有考虑儿科人群的年龄特异性因素,限制了其对年轻患者的适用性。本研究旨在修改TRISS以考虑儿童年龄(Peds-TRISS),并评估其相对于原始TRISS的性能。我们还评估了生存结果,以探索该模型在各种临床环境中的潜在效用。这些努力与旨在减少可预防死亡率和支持可持续发展目标的质量改进举措相一致。方法:这项回顾性队列研究纳入了2011年至2019年期间在哥伦比亚一家医院接受治疗的18岁以下患者。使用逻辑回归计算TRISS协变量的新系数,将年龄视为连续变量。基于判别(C统计量)和校正对模型性能进行评价,并将Peds-TRISS与原始TRISS进行比较。内部验证采用自举重采样。生存结果评估使用M和Z统计,这通常用于国际创伤结果比较。结果:该研究纳入1013例儿童患者,中位年龄为12岁(IQR 5-15),其中73%为男性。造成伤害的主要原因是交通事故(31.1%)、跌倒(28.8%)和殴打(28.7%)。总死亡率为5.7%。Peds-TRISS模型具有良好的校正性(HL = 9.7, p = 0.3)和判别性(C统计量= 0.98,95% CI 0.97-0.99),与原TRISS模型的ROC曲线比较无统计学差异。内部验证表明Peds-TRISS具有较强的性能。M和Z统计量分别为0.93和0,表明预期生存率与观察生存率无显著差异。结论:大多数死亡发生在青少年中,并且是由于故意伤害。Peds-TRISS模型与原始TRISS相比,在性能上有部分改进,在校准方面有更好的结果,尽管在辨别方面没有。这些发现突出了为特定人群定制模型的潜力。建议进行前瞻性、多中心研究,以进一步验证该模型在不同环境下的实用性。
Quality of pediatric trauma care: development of an age-adjusted TRISS model and survival benchmarking in a major trauma center.
Background: Pediatric trauma is a major global health concern, accounting for a substantial proportion of deaths and disease burden from age 5 onwards. Effective triage and management are essential in pediatric trauma care, and prediction models such as the Trauma Injury Severity Score (TRISS) play a crucial role in estimating survival probability and guiding quality improvement. However, TRISS does not account for age-specific factors in pediatric populations, limiting its applicability to younger patients. This study aimed to modify TRISS to account for age for children (Peds-TRISS) and to evaluate its performance relative to the original TRISS. We also assessed survival outcomes to explore the model's potential utility across various clinical settings. These efforts align with quality improvement initiatives to reduce preventable mortality and supporting sustainable development goals.
Methods: This retrospective cohort study included patients under 18 years of age who were treated at a hospital in Colombia between 2011 and 2019. New coefficients for TRISS covariates were calculated using logistic regression, with age treated as a continuous variable. Model performance was evaluated based on discrimination (C statistic) and calibration, comparing Peds-TRISS with the original TRISS. Internal validation was conducted using bootstrap resampling. Survival outcomes were assessed using the M and Z statistics, which are commonly used for international trauma outcome comparisons.
Results: The study included 1,013 pediatric patients with a median age of 12 years (IQR 5-15), of whom 73% were male. The leading causes of injury were traffic accidents (31.1%), falls (28.8%), and assaults (28.7%). The overall mortality rate was 5.7%. The Peds-TRISS model demonstrated good calibration (HL = 9.7, p = 0.3) and discrimination (C statistic = 0.98, 95% CI 0.97-0.99), with no statistically significant difference in the ROC curve comparison with the original TRISS. Internal validation demonstrated strong performance of Peds-TRISS. The M and Z statistics were 0.93 and 0, respectively, indicating no significant differences between expected and observed survival rates.
Conclusions: Most fatalities occurred among adolescents and were due to intentional injuries. The Peds-TRISS model showed a partial improvement in performance compared to the original TRISS, with superior results in terms of calibration, although not in discrimination. These findings highlight the potential of model customization for specific populations. Prospective, multicenter studies are recommended to further validate the model's utility across diverse settings.
期刊介绍:
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.