肝移植的特殊技术:活体肝移植联合右后段和扩展左叶移植辅助部分原位肝移植和双叶肝移植。

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jasper S. Rajasekar, Ashwin Rammohan, Mohamed Rela
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引用次数: 0

摘要

活体供肝移植(LDLT)是亚洲肝脏移植的主要形式,LDLT技术的进步扩大了同种异体移植的范围,超出了常用的右叶(RL)。本文综述了一些鲜为人知的同种异体移植物和LDLT技术,包括右后段移植物(RPSG)、双叶肝移植(DLLT)、辅助部分原位肝移植(APOLT)和带尾状核的扩展左叶移植物,重点介绍了技术方面、目前的证据及其在当代LDLT实践中的适应症。第一部分研究rpsg,重点关注其作为RL移植物的替代方案的潜力,特别是当体积研究表明供体右侧后段较大时。它涉及供体选择,手术技术和潜在的并发症。接下来,文章探讨了DLLT,它通过两个供体的部分移植物来优化移植物体积。重点是伦理考虑、手术挑战和血流动力学风险,如移植物萎缩,强调仔细选择供体和精心规划的重要性。APOLT部分涵盖了其在治疗急性肝衰竭(ALF)和代谢性肝病中的应用。讨论了该技术在ALF中支持肝功能的能力,同时避免了天然肝脏再生时的长期免疫抑制,以及患者选择标准和随访要求。最后,本文综述了带尾状核的左叶移植物在小个子成人和大龄儿童中的应用,以增加移植物的功能体积并改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Special Techniques of Liver Transplantation: Living Donor Liver Transplantation With Right Posterior Sector Grafts and Extended Left Lobe Grafts; Auxiliary Partial Orthotopic Liver Transplantation, and Dual-Lobe Liver Transplantation
Living donor liver transplantation (LDLT) constitutes the majority of liver transplants in Asia and advancements in LDLT techniques have expanded the range of allografts beyond the commonly used right lobe (RL). This review provides a comprehensive overview of lesser-known variants of allografts and LDLT techniques which include right posterior sector grafts (RPSG), dual-lobe liver transplantation (DLLT), auxiliary partial orthotopic liver transplantation (APOLT), and extended left lobe grafts with caudate concentrating on the technical aspects, current evidence, and their indications in contemporary practice of LDLT. The first section examines RPSGs, focussing on their potential as an alternative to RL grafts particularly when volumetric studies indicate a larger right posterior sector in donors. It addresses donor selection, surgical techniques, and potential complications. Next, the article explores DLLT, which optimizes graft volume through partial grafts from two donors. The emphasis is on the ethical considerations, surgical challenges, and haemodynamic risks, such as graft atrophy, highlighting the importance of careful donor selection and meticulous planning. The section on APOLT covers its application in treating acute liver failure (ALF) and metabolic liver diseases. The technique’s ability to support liver function in ALF while avoiding long-term immunosuppression when the native liver regenerates is discussed, along with patient selection criteria and follow-up requirements. Finally, the review addresses left lobe grafts with caudate used in smaller adults and older children to increase functional graft volume and improve outcomes.
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来源期刊
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.90
自引率
16.70%
发文量
537
审稿时长
64 days
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