干细胞和生物支架治疗心血管疾病:新见解。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2024-12-12 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1472103
Zahra Sadat Razavi, Simin Farokhi, Golnaz Mahmoudvand, Arian Karimi-Rouzbahani, Bahareh Farasati-Far, Samaneh Tahmasebi-Ghorabi, Hamidreza Pazoki-Toroudi, Masoud Saadat-Fakhr, Hamed Afkhami
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引用次数: 0

摘要

心血管疾病的死亡率和发病率在全世界都很常见。为了改善这一患者群体的生存和生活质量,正在作出广泛的努力,以建立有效的治疗方式。似乎需要新的治疗方案。除了治疗心血管疾病外,细胞疗法也是最有前途的医疗平台之一。该领域最有效的治疗方法之一是干细胞治疗。在干细胞生物学中,多能干细胞和多能干细胞分为两种类型。基于多种证据,有证据表明干细胞疗法可以作为心血管疾病的治疗方法。干细胞治疗在人类中的有效性已经在几项临床试验中得到了研究。尽管与干细胞治疗相关的挑战,似乎解决这些问题可能导致干细胞用于心血管疾病患者。这可能是一种有效的治疗方法。通过将这些干细胞安装在生物支架上,它们的作用可以得到增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights.

Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival and quality of life for this patient population, extensive efforts are being made to establish effective therapeutic modalities. New treatment options are needed, it seems. In addition to treating cardiovascular diseases, cell therapy is one of the most promising medical platforms. One of the most effective therapeutic approaches in this area is stem cell therapy. In stem cell biology, multipotent stem cells and pluripotent stem cells are divided into two types. There is evidence that stem cell therapy could be used as a therapeutic approach for cardiovascular diseases based on multiple lines of evidence. The effectiveness of stem cell therapies in humans has been studied in several clinical trials. In spite of the challenges associated with stem cell therapy, it appears that resolving them may lead to stem cells being used in cardiovascular disease patients. This may be an effective therapeutic approach. By mounting these stem cells on biological scaffolds, their effect can be enhanced.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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