{"title":"高血压发病年龄与慢性肾脏疾病的关系：美国人口的横断面研究","authors":"Lanlan Qiu, Bo Wu","doi":"10.3389/fcvm.2024.1426953","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD.</p><p><strong>Objective: </strong>We investigated the relationship between the age of onset of hypertension and CKD.</p><p><strong>Method: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension (<i>n</i> = 19,516); Group 2, age of onset <35 years (<i>n</i> = 2,180); Group 3, 35≤ age of onset <45 years (<i>n</i> = 2,128); and Group 4, age of onset ≥45 years (<i>n</i> = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD.</p><p><strong>Results: </strong>After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53-4.14, <i>P</i> < 0.001; Group 3 OR: 1.59, 95% CI: 1.01-2.51, <i>P</i> = 0.048; Group 4 OR: 1.54, 95% CI: 1.00-2.38, <i>P</i> = 0.050).</p><p><strong>Conclusions: </strong>There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1426953"},"PeriodicalIF":2.8000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669582/pdf/","citationCount":"0","resultStr":"{\"title\":\"The relationship between the age of onset of hypertension and chronic kidney disease: a cross-sectional study of the American population.\",\"authors\":\"Lanlan Qiu, Bo Wu\",\"doi\":\"10.3389/fcvm.2024.1426953\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD.</p><p><strong>Objective: </strong>We investigated the relationship between the age of onset of hypertension and CKD.</p><p><strong>Method: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension (<i>n</i> = 19,516); Group 2, age of onset <35 years (<i>n</i> = 2,180); Group 3, 35≤ age of onset <45 years (<i>n</i> = 2,128); and Group 4, age of onset ≥45 years (<i>n</i> = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD.</p><p><strong>Results: </strong>After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53-4.14, <i>P</i> < 0.001; Group 3 OR: 1.59, 95% CI: 1.01-2.51, <i>P</i> = 0.048; Group 4 OR: 1.54, 95% CI: 1.00-2.38, <i>P</i> = 0.050).</p><p><strong>Conclusions: </strong>There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.</p>\",\"PeriodicalId\":12414,\"journal\":{\"name\":\"Frontiers in Cardiovascular Medicine\",\"volume\":\"11 \",\"pages\":\"1426953\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-12-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669582/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cardiovascular Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fcvm.2024.1426953\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcvm.2024.1426953","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景：高血压可损害多个靶器官。高血压发病年龄越小，心血管疾病（CVD）和心血管死亡的风险越大。慢性肾脏疾病（CKD）是高血压的并发症，但很少有研究探讨高血压发病年龄与CKD的关系。目的：探讨高血压发病年龄与慢性肾病的关系。方法：我们分析2007-2018年国家健康与营养检查调查（NHANES）的数据。共有30,613名参与者被分为四组。1组，无高血压（n = 19,516）；第二组，发病年龄n = 2180)；第3组，35≤发病年龄n = 2128)；4组发病年龄≥45岁（n = 6789）。采用Logistic回归分析评价高血压发病年龄与慢性肾病的关系。结果：在调整了潜在的混杂因素后，与没有高血压的患者相比，高血压发病年龄越小，发生CKD的风险越大(第二组OR: 2.52, 95% CI: 1.53-4.14, P P = 0.048；第四组OR: 1.54, 95% CI: 1.00-2.38, P = 0.050)。结论：高血压发病年龄与慢性肾病有很强的相关性。高血压发病年龄越小，患慢性肾病的风险越大。
The relationship between the age of onset of hypertension and chronic kidney disease: a cross-sectional study of the American population.
Background: Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD.
Objective: We investigated the relationship between the age of onset of hypertension and CKD.
Method: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension (n = 19,516); Group 2, age of onset <35 years (n = 2,180); Group 3, 35≤ age of onset <45 years (n = 2,128); and Group 4, age of onset ≥45 years (n = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD.
Results: After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53-4.14, P < 0.001; Group 3 OR: 1.59, 95% CI: 1.01-2.51, P = 0.048; Group 4 OR: 1.54, 95% CI: 1.00-2.38, P = 0.050).
Conclusions: There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.
期刊介绍：
Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers?
At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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