土耳其溶血性尿毒症患者临床产志贺毒素大肠杆菌菌株的血清群和毒素变异

IF 1.9 2区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY
Elif Okumuş, Aynur Karadenizli, Elif Bahat Özdoğan, Kenan Bek
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引用次数: 0

摘要

产志贺毒素大肠杆菌(STEC)是指一组可引起感染的细菌,这种感染在世界范围内很常见,并构成严重的公共卫生问题,因为它们可导致出血性结肠炎和溶血性尿毒症综合征(HUS)等疾病。溶血性尿毒综合征是一种以微血管致病性溶血性贫血、血小板减少症和肾功能衰竭为特征的疾病。测定产志毒素大肠杆菌的血清群和毒素谱对于估计其致病潜力和预测流行病学变化具有重要意义。本研究分析了土耳其46名儿童溶血性尿毒综合征患者的产志贺毒素大肠杆菌分离物,使用聚合酶链反应从2016年至2019年收集的粪便样本中确定O血清群和志贺毒素(Stx)变体。其中25例(54.3%)为0-2岁年龄组。其中82.6%为非o157血清组。检出最多的血清组为O145(32.6%), 28.3%的血清组未分型。其中Stx1单株8株(17.4%),Stx2单株26株(56.5%),Stx1和Stx2兼有12株(26.1%)。Stx变异出现在7种组合中,最常见的是单独的Stx2a(56.5%)。Stx2a患者的住院时间长于其他变异患者(p = 0.01)。这项研究强调了土耳其的一个令人担忧的趋势,在那里,非o157血清群,特别是O145血清群,成为溶血性尿毒综合征的普遍原因。Stx2a在我们的分离株中占主导地位,并且Stx2a患者住院时间较长,这支持了将该变异与严重临床结果(包括溶血性尿毒综合征)联系起来的研究结果。了解这些Stx变异的动态将有助于更好地准备和减轻我们人群中产志贺毒素大肠杆菌感染的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serogroups and Toxin Variants of Clinical Shiga Toxin-Producing Escherichia coli Strains Isolated from Patients with Hemolytic Uremic Syndrome in Turkey.

Shiga toxin-producing Escherichia coli (STEC) refers to a group of bacteria that can cause infections, which are common worldwide and pose a serious public health problem, as they can lead to conditions such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). HUS is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. Determination of serogroups and toxin profiles of STEC is important for estimating their disease-causing potential and predicting epidemiological changes. This study analyzed STEC isolates from 46 pediatric HUS patients across Turkey, using polymerase chain reaction to determine O serogroups and Shiga toxin (Stx) variants from stool samples collected between 2016 and 2019. Of the patients, 25 (54.3%) were in the 0-2 age group. Of the isolates, 82.6% were non-O157 serogroup. The most detected serogroup was O145 (32.6%), and 28.3% of the serogroups were not typed. Of the strains, 8 (17.4%) had Stx1 alone, 26 (56.5%) had Stx2 alone, and 12 (26.1%) had both Stx1 and Stx2. The Stx variants occurred in seven combinations, with the most common being Stx2a alone (56.5%). The duration of hospitalization for patients with Stx2a was found to be longer than that for patients with other variants (p = 0.01). This study highlights a concerning trend in Turkey, where non-O157 serogroups, particularly O145, emerged as prevalent causes of HUS. The predominance of Stx2a among our isolates and the longer hospitalization duration for patients with Stx2a support findings linking this variant to severe clinical outcomes, including HUS. Understanding the dynamics of these Stx variants will help better prepare for and mitigate the impacts of STEC infections in our population.

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来源期刊
Foodborne pathogens and disease
Foodborne pathogens and disease 医学-食品科技
CiteScore
5.30
自引率
3.60%
发文量
80
审稿时长
1 months
期刊介绍: Foodborne Pathogens and Disease is one of the most inclusive scientific publications on the many disciplines that contribute to food safety. Spanning an array of issues from "farm-to-fork," the Journal bridges the gap between science and policy to reduce the burden of foodborne illness worldwide. Foodborne Pathogens and Disease coverage includes: Agroterrorism Safety of organically grown and genetically modified foods Emerging pathogens Emergence of drug resistance Methods and technology for rapid and accurate detection Strategies to destroy or control foodborne pathogens Novel strategies for the prevention and control of plant and animal diseases that impact food safety Biosecurity issues and the implications of new regulatory guidelines Impact of changing lifestyles and consumer demands on food safety.
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