Gabriele Lo Buglio, Marta Mirabella, Laura Muzi, Tommaso Boldrini, Erika Cerasti, Jone Bjornestad, Flavia Fiorentino, Andrea Polari, Eleonora Riccioli, Michele Angelo Rugo, Marco Solmi, Vittorio Lingiardi, Annalisa Tanzilli
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The secondary aim (b) was providing a comprehensive clinical description of individuals with both CHR-P and EDs/ED-related symptoms.</p><p><strong>Methods: </strong>Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review and meta-analysis, searching PubMed/(EBSCO)PsycINFO/Web of Science for studies published between 01/01/2018 and 30/05/2023, including individuals with CHR-P and EDs/ED symptoms (PROSPERO CRD42023488792). Quality assessment was performed using the Newcastle-Ottawa Scale (NOS). We performed a meta-regression model on the proportion of EDs in CHR-P individuals (primary aim) and conducted a narrative synthesis (secondary aim).</p><p><strong>Results: </strong>We included 26 articles, reporting on 2,060 and 589 subjects for study aim (a) and (b), respectively (mean NOS score = 6.38). The prevalence of EDs in CHR-P individuals was 0.05 (95% CI 0.3-0.8). 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引用次数: 0
摘要
背景：饮食失调（EDs）是临床精神病高危人群（chrp）中研究最少的精神障碍之一。本系统综述和荟萃分析的主要目的是确定chrp患者ED诊断的预测因素。次要目的(b)是提供具有chrp和ed / ed相关症状的个体的全面临床描述。方法：系统评价和荟萃分析首选报告项目（PRISMA） 2020-合规系统评价和荟萃分析，检索PubMed/(EBSCO)PsycINFO/Web of Science在2018年1月1日至2023年5月30日期间发表的研究，包括有chrp和ED /ED症状的个体（PROSPERO CRD42023488792）。采用纽卡斯尔-渥太华量表（NOS）进行质量评估。我们对chrp个体中ed的比例进行了meta回归模型（主要目标），并进行了叙事综合（次要目标）。结果：我们纳入了26篇文章，分别报道了2060名和589名受试者，用于研究目的(a)和(b) （NOS平均评分= 6.38）。CHR-P患者ed患病率为0.05 （95% CI 0.3-0.8）。没有任何因素对CHR-P个体的ed比例有显著影响。由于报道ed相关症状和抗精神病药物处方的研究数量不足，meta回归模型中无法包括ed相关症状和抗精神病药物处方，这一结果受到限制。叙事综合提供了chrp和ED/ED相关症状的个体特征；然而，纳入的研究数量有限，不足以支持明确的结论。结论：在chrp个体中没有发现显著的ed预测因子。跨诊断、前瞻性队列研究是有必要的，以检查chrp和ed患者的长期结果，超越诊断孤岛。证据水平：1 .系统评价和荟萃分析。
Eating disorders and disordered eating symptoms in individuals at clinical high risk for psychosis: a systematic review and meta-analysis.
Background: Eating disorders (EDs) are among the least studied mental disorders in individuals at clinical high risk for psychosis (CHR-P). The primary aim (a) of this systematic review and meta-analysis was to identify factors predicting ED diagnoses in CHR-P individuals. The secondary aim (b) was providing a comprehensive clinical description of individuals with both CHR-P and EDs/ED-related symptoms.
Methods: Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review and meta-analysis, searching PubMed/(EBSCO)PsycINFO/Web of Science for studies published between 01/01/2018 and 30/05/2023, including individuals with CHR-P and EDs/ED symptoms (PROSPERO CRD42023488792). Quality assessment was performed using the Newcastle-Ottawa Scale (NOS). We performed a meta-regression model on the proportion of EDs in CHR-P individuals (primary aim) and conducted a narrative synthesis (secondary aim).
Results: We included 26 articles, reporting on 2,060 and 589 subjects for study aim (a) and (b), respectively (mean NOS score = 6.38). The prevalence of EDs in CHR-P individuals was 0.05 (95% CI 0.3-0.8). No factor had a significant effect on the proportion of EDs in CHR-P individuals. This result is limited by the inability to include ED-related symptoms and antipsychotic prescriptions in the meta-regression model, due to an insufficient number of studies reporting on these variables. The narrative synthesis offers a characterization of individuals with both CHR-P and ED/ED-related symptoms; however, the limited number of included studies is insufficient to support definitive conclusions.
Conclusions: No significant predictor of EDs was found in CHR-P individuals. Transdiagnostic, prospective cohort studies are warranted to examine long-term outcomes in individuals with both CHR-P and EDs, beyond diagnostic silos.
Level of evidence: I. Systematic review and meta-analysis.
期刊介绍：
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.
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