{"title":"美国成人血液学指标中新烟碱类与炎症的关系：NHANES 2015-2016。","authors":"Amruta M Godbole, Aimin Chen, Ann M Vuong","doi":"10.1097/EE9.0000000000000358","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects.</p><p><strong>Methods: </strong>National Health and Nutrition Examination Survey (NHANES) 2015-2016 data were used to estimate associations between neonicotinoid exposure and inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) using linear and multinomial logistic regression models. Sex was evaluated as a potential modifier.</p><p><strong>Results: </strong>Detection of any parent neonicotinoid (<i>β</i> = -0.62, 95% confidence interval [CI] = -0.98, -0.26) and imidacloprid (<i>β</i> = -0.48, 95% CI = -0.87, -0.10) was associated with decreased CLR. Clothianidin was linked to reduced MLR (<i>β</i> = -0.04, 95% CI = -0.07, -0.02), but increased lymphocyte-to-monocyte ratio (<i>β</i> = 0.52, 95% CI = 0.27, 0.77). Higher dNLR (<i>β</i> = 0.85; 95% CI = 0.26, 1.43) was noted with detection of any neonicotinoid metabolite. Moderately high PLR was observed with detection of any neonicotinoid metabolite (relative risk ratio [RRR] = 1.63, 95% CI = 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR = 2.19, 95% CI = 1.40, 3.41). Sex-modified analyses showed positive associations in males and inverse associations in females for MHR (<i>P</i> <sub><i>int</i></sub> = 0.099, clothianidin), PLR (<i>P</i> <sub><i>int</i></sub> = 0.026, clothianidin), and SII (<i>P</i> <sub><i>int</i></sub> = 0.056, any parent neonicotinoid; <i>P</i> <sub><i>int</i></sub> = 0.002, clothianidin), while the opposite pattern was noted with CLR (<i>P</i> <sub><i>int</i></sub> = 0.073, any parent neonicotinoid) and NLR (<i>P</i> <sub><i>int</i></sub> = 0.084, clothianidin).</p><p><strong>Conclusion: </strong>Neonicotinoids may be associated with inflammatory changes, with potential sexual dimorphism. Further studies are required to explore these findings.</p>","PeriodicalId":11713,"journal":{"name":"Environmental Epidemiology","volume":"9 1","pages":"e358"},"PeriodicalIF":3.3000,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671084/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.\",\"authors\":\"Amruta M Godbole, Aimin Chen, Ann M Vuong\",\"doi\":\"10.1097/EE9.0000000000000358\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects.</p><p><strong>Methods: </strong>National Health and Nutrition Examination Survey (NHANES) 2015-2016 data were used to estimate associations between neonicotinoid exposure and inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) using linear and multinomial logistic regression models. Sex was evaluated as a potential modifier.</p><p><strong>Results: </strong>Detection of any parent neonicotinoid (<i>β</i> = -0.62, 95% confidence interval [CI] = -0.98, -0.26) and imidacloprid (<i>β</i> = -0.48, 95% CI = -0.87, -0.10) was associated with decreased CLR. Clothianidin was linked to reduced MLR (<i>β</i> = -0.04, 95% CI = -0.07, -0.02), but increased lymphocyte-to-monocyte ratio (<i>β</i> = 0.52, 95% CI = 0.27, 0.77). Higher dNLR (<i>β</i> = 0.85; 95% CI = 0.26, 1.43) was noted with detection of any neonicotinoid metabolite. Moderately high PLR was observed with detection of any neonicotinoid metabolite (relative risk ratio [RRR] = 1.63, 95% CI = 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR = 2.19, 95% CI = 1.40, 3.41). Sex-modified analyses showed positive associations in males and inverse associations in females for MHR (<i>P</i> <sub><i>int</i></sub> = 0.099, clothianidin), PLR (<i>P</i> <sub><i>int</i></sub> = 0.026, clothianidin), and SII (<i>P</i> <sub><i>int</i></sub> = 0.056, any parent neonicotinoid; <i>P</i> <sub><i>int</i></sub> = 0.002, clothianidin), while the opposite pattern was noted with CLR (<i>P</i> <sub><i>int</i></sub> = 0.073, any parent neonicotinoid) and NLR (<i>P</i> <sub><i>int</i></sub> = 0.084, clothianidin).</p><p><strong>Conclusion: </strong>Neonicotinoids may be associated with inflammatory changes, with potential sexual dimorphism. Further studies are required to explore these findings.</p>\",\"PeriodicalId\":11713,\"journal\":{\"name\":\"Environmental Epidemiology\",\"volume\":\"9 1\",\"pages\":\"e358\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-12-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671084/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Epidemiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/EE9.0000000000000358\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/EE9.0000000000000358","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：毒理学研究表明，新烟碱类会增加氧化应激和炎症，但很少有流行病学研究探讨这些影响。方法:使用2015-2016年国家健康与营养检查调查（NHANES）数据来估计新烟碱暴露与炎症标志物之间的关系，包括c反应蛋白与淋巴细胞计数比（CLR）、单核细胞与高密度脂蛋白比（MHR）、单核细胞与淋巴细胞比（MLR）、中性粒细胞与淋巴细胞比（NLR）、衍生NLR （dNLR）、淋巴细胞与单核细胞比、血小板与淋巴细胞比（PLR）、和系统免疫炎症指数（SII）使用线性和多项逻辑回归模型。性别被评估为潜在的修饰因素。结果：检测任何亲本新烟碱类（β = -0.62, 95%可信区间[CI] = -0.98, -0.26）和吡虫啉（β = -0.48, 95% CI = -0.87, -0.10）与CLR降低相关。Clothianidin与MLR降低相关（β = -0.04, 95% CI = -0.07, -0.02），但增加淋巴细胞/单核细胞比率（β = 0.52, 95% CI = 0.27, 0.77）。更高的dNLR (β = 0.85；95% CI = 0.26, 1.43)，检测到任何新烟碱代谢物。检测到新烟碱类代谢物（相对危险比[RRR] = 1.63, 95% CI = 1.27, 2.09）或5-羟基吡虫啉（RRR = 2.19, 95% CI = 1.40, 3.41）时，PLR为中等高。性别修饰分析显示，男性的MHR （P int = 0.099，噻虫胺）、PLR （P int = 0.026，噻虫胺）和SII （P int = 0.056，任何亲本新烟碱）呈正相关，女性呈负相关；CLR （P int = 0.073，任何亲本新烟碱类）和NLR （P int = 0.084，噻虫胺类）则相反。结论：新烟碱类杀虫剂可能与炎症变化有关，具有潜在的性别二态性。需要进一步的研究来探索这些发现。
Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.
Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects.
Methods: National Health and Nutrition Examination Survey (NHANES) 2015-2016 data were used to estimate associations between neonicotinoid exposure and inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) using linear and multinomial logistic regression models. Sex was evaluated as a potential modifier.
Results: Detection of any parent neonicotinoid (β = -0.62, 95% confidence interval [CI] = -0.98, -0.26) and imidacloprid (β = -0.48, 95% CI = -0.87, -0.10) was associated with decreased CLR. Clothianidin was linked to reduced MLR (β = -0.04, 95% CI = -0.07, -0.02), but increased lymphocyte-to-monocyte ratio (β = 0.52, 95% CI = 0.27, 0.77). Higher dNLR (β = 0.85; 95% CI = 0.26, 1.43) was noted with detection of any neonicotinoid metabolite. Moderately high PLR was observed with detection of any neonicotinoid metabolite (relative risk ratio [RRR] = 1.63, 95% CI = 1.27, 2.09) or 5-hydroxy-imidacloprid (RRR = 2.19, 95% CI = 1.40, 3.41). Sex-modified analyses showed positive associations in males and inverse associations in females for MHR (Pint = 0.099, clothianidin), PLR (Pint = 0.026, clothianidin), and SII (Pint = 0.056, any parent neonicotinoid; Pint = 0.002, clothianidin), while the opposite pattern was noted with CLR (Pint = 0.073, any parent neonicotinoid) and NLR (Pint = 0.084, clothianidin).
Conclusion: Neonicotinoids may be associated with inflammatory changes, with potential sexual dimorphism. Further studies are required to explore these findings.
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