肺炎克雷伯菌感染社区获得性肺炎的临床特点及死亡危险因素分析。

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-12-16 DOI:10.1016/j.diagmicrobio.2024.116660

Xiaofeng Yu , Lijun Suo , Xiao Sun , Tianyu Sun , Li Wang , Xiaowei Qi , Aiming Hou , Jiahui Luan , Haiyan Wang , Yi Zhao , Bo Liu , Hongyun Cao

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引用次数: 0

摘要

由肺炎克雷伯菌（KP）引起的社区获得性肺炎（CAP）导致高死亡率。本研究纳入121例由高毒力或耐药KP菌株引起的CAP患者的特点及危险因素，这在以往的研究中报道较少。我们发现，高毒力KP和产生esblp的KP感染都不会影响死亡率（P < 0.05），而qSOFA评分升高（比值比[OR] 4.50, 95%可信区间[CI] 1.55-12.76, P = 0.005）和APACHE-II评分升高（比值比[OR] 1.30, 95% CI 1.13-1.48, P < 0.001）是死亡率的独立危险因素。此外，qSOFA预测所有患者、ICU患者和非ICU患者死亡率的曲线下面积（auc）分别为0.82、0.74和0.81。qSOFA或APACHE-II评分升高被认为是28天死亡率的独立危险因素。qSOFA评分可以很好地预测KP CAP患者的死亡率。

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Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae

Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae (KP) results in high mortality. 121 cases were included in this study to explore the characteristics and risk factors of CAP patients caused by hypervirulent or resistant KP strains, which were limited reported in previous studies. We found that neither hypervirulent KP nor ESBL-producing KP infections affect mortality (P > 0.05), while increased qSOFA score (odds ratio [OR] 4.50, 95% confidence interval [CI] 1.55–12.76, P = 0.005) and APACHE-II score (OR 1.30, 95% CI 1.13–1.48, P < 0.001) were independent risk factors for mortality. In addition, the areas under the curve (AUCs) of qSOFA in predicting the mortality rate of all patients, ICU patients, and non-ICU patients were 0.82, 0.74, and 0.81, respectively. Elevated qSOFA or APACHE-II scores were considered independent risk factors for 28-day mortality. The qSOFA score was a good predictor of mortality among KP CAP patients.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.