EMZL复发或进展后患者bcl6蛋白表达异常：附2例报告

IF 2.4 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2024-12-26 DOI:10.1186/s13000-024-01593-z

Ming Zhang, Jianli Qu, Weiwei Guo, Yi Liu, Wei Zhang

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引用次数: 0

摘要

结外粘膜相关淋巴组织边缘区淋巴瘤（EMZL）是一种可累及不同解剖部位的惰性b细胞淋巴瘤。EMZL来源于生发后中心边缘区B细胞，通常缺乏bcl-6的表达。在此，我们报告了两例治疗后的EMZL病例，在复发或进展后获得的标本中观察到意外的bcl-6蛋白表达。这与原始标本的bcl-6阴性形成对比。此外，我们通过荧光原位杂交分析证实，在复发的EMZL病例中观察到的bcl6表达改变与bcl6基因重排无关。对相关文献进行了回顾和总结，以提高对这一现象的理解，特别是病理学家。

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Aberrant bcl6 protein expression in patients with EMZL following recurrence or progression: case report of two cases.

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) is an indolent B-cell lymphoma that can involve various anatomic sites. EMZL is derived from post-germinal center marginal zone B cells and typically lacks bcl-6 expression. Herein, we report two post-treatment cases of EMZL where unexpected bcl-6 protein expression was observed in specimens obtained following recurrence or progression. This contrasts with the primary specimens, which were negative for the bcl-6. Additionally, we confirm that the altered bcl6 expression observed in relapsed EMZL cases is independent of BCL6 gene rearrangement, as demonstrated by fluorescence in situ hybridization analysis. Relevant literature was reviewed and summarized to enhance the understanding of this phenomenon, particularly for pathologists.

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).