支气管肺泡灌洗液中的(1,3)- β - d -葡聚糖：诊断曲霉乳杆菌引起的侵袭性肺部感染的有用生物标志物？

IF 2.4 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2024-12-28 DOI:10.1186/s13000-024-01589-9

Haiyan Ye, Jinhui He, Jing Huang, Patrick Chu, Junru Liu, Rosana Wing-Shan Poon, Fanfan Xing, Simon Kam-Fai Lo, Ricky Wing-Tong Lau, Jasper Fuk-Woo Chan, Susanna Kar-Pui Lau, Kelvin Hei-Yeung Chiu

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引用次数: 0

摘要

曲霉红曲霉是一种罕见的透明霉菌引起侵袭性真菌感染的人，直到经常使用抗真菌预防免疫功能低下的宿主。由于曲霉菌感染的高死亡率，早期识别和治疗至关重要。以往的病例报告表明，血清(1,3)- β - d -葡聚糖（BG）是曲霉感染的诊断辅助工具之一。在这里，我们报告了第一例肺部曲霉菌感染阴性血清BG但阳性支气管肺泡灌洗液（BAL） BG。这可能表明BAL BG是一种有用的微生物标志物，可以快速识别这种致命的侵袭性真菌感染（IFI）。但它应与临床表现、影像学和其他实验室结果一起解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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(1, 3)-beta-D-Glucan in bronchoalveolar lavage fluid: a useful biomarker in diagnosis of invasive pulmonary infection caused by Hormographiella aspergillata?

Hormographiella aspergillata is a rare hyaline mold causing invasive fungal infection in humans, until the frequent use of antifungal prophylaxis in immunocompromised hosts. Due to the high mortality of H. aspergillata infection, early recognition and treatment are crucial. Previous case reports suggested that serum (1,3)-beta-D-Glucan (BG) is one of the diagnostic aids for H. aspergillata infection. Here we report for the first time a case of pulmonary H. aspergillata infection with a negative serum BG but positive bronchoalveolar lavage fluid (BAL) BG. This may suggest that BAL BG is a useful and additional microbiological marker for prompt identification of this fatal invasive fungal infection (IFI). But it should be interpreted together with the clinical presentation, imaging, and other laboratory results.

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).