{"title":"自组装肽P11-4对牙釉质侵蚀作用的对比分析：共聚焦激光扫描显微镜研究。","authors":"Buse Yilmaz Sen, Merve Akcay","doi":"10.1007/s00784-024-06115-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P<sub>11</sub>-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.</p><p><strong>Materials and methods: </strong>Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P<sub>11</sub>-4 peptide (Curodont-Repair), stannous/Sn<sup>2+</sup> containing solution (8% Sn<sup>2+</sup>), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P<sub>11</sub>-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn<sup>2+</sup>+Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)]. Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day. In combined-groups, a home-use dental-care product was applied daily at the end of each cycle day. After the cycle, lesion depth and fluorescence were analyzed using confocal-laser-scanning-microscopy, and results were statistically evaluated using paired t-tests, ANOVA, and Tukey's post-hoc tests.</p><p><strong>Results: </strong>The P<sub>11</sub>-4 group was significantly more effective among the professional-only groups in both parameters (p<0.001). All combined-groups were determined to be statistically more successful than their respective professional-groups in both parameters (p<0.05). Based on lesion depth data, it was observed that the P<sub>11</sub>-4 and stannous-containing combined-groups showed statistically similar results (p>0.05). In terms of lesion fluorescence data, the P<sub>11</sub>-4 combined-group was found to be statistically more successful than all other study groups (p<0.05).</p><p><strong>Conclusion: </strong>The self-assembling peptide P<sub>11</sub>-4 was determined to exhibit the best preventive and protective anti-erosive effect in both professional and combined applications.</p><p><strong>Clinical relevance: </strong>A positive relationship was observed between the support of professional applications with home-use daily-dental-care products and protection against erosive lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"29"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative analysis of the effect of self-assembling peptide P<sub>11</sub>-4 on enamel erosion: a confocal laser scanning microscopy study.\",\"authors\":\"Buse Yilmaz Sen, Merve Akcay\",\"doi\":\"10.1007/s00784-024-06115-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P<sub>11</sub>-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.</p><p><strong>Materials and methods: </strong>Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P<sub>11</sub>-4 peptide (Curodont-Repair), stannous/Sn<sup>2+</sup> containing solution (8% Sn<sup>2+</sup>), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P<sub>11</sub>-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn<sup>2+</sup>+Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)]. Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day. In combined-groups, a home-use dental-care product was applied daily at the end of each cycle day. After the cycle, lesion depth and fluorescence were analyzed using confocal-laser-scanning-microscopy, and results were statistically evaluated using paired t-tests, ANOVA, and Tukey's post-hoc tests.</p><p><strong>Results: </strong>The P<sub>11</sub>-4 group was significantly more effective among the professional-only groups in both parameters (p<0.001). All combined-groups were determined to be statistically more successful than their respective professional-groups in both parameters (p<0.05). Based on lesion depth data, it was observed that the P<sub>11</sub>-4 and stannous-containing combined-groups showed statistically similar results (p>0.05). In terms of lesion fluorescence data, the P<sub>11</sub>-4 combined-group was found to be statistically more successful than all other study groups (p<0.05).</p><p><strong>Conclusion: </strong>The self-assembling peptide P<sub>11</sub>-4 was determined to exhibit the best preventive and protective anti-erosive effect in both professional and combined applications.</p><p><strong>Clinical relevance: </strong>A positive relationship was observed between the support of professional applications with home-use daily-dental-care products and protection against erosive lesions.</p>\",\"PeriodicalId\":10461,\"journal\":{\"name\":\"Clinical Oral Investigations\",\"volume\":\"29 1\",\"pages\":\"29\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-12-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Investigations\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00784-024-06115-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-024-06115-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Comparative analysis of the effect of self-assembling peptide P11-4 on enamel erosion: a confocal laser scanning microscopy study.
Objectives: This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P11-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.
Materials and methods: Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P11-4 peptide (Curodont-Repair), stannous/Sn2+ containing solution (8% Sn2+), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P11-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn2++Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)]. Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day. In combined-groups, a home-use dental-care product was applied daily at the end of each cycle day. After the cycle, lesion depth and fluorescence were analyzed using confocal-laser-scanning-microscopy, and results were statistically evaluated using paired t-tests, ANOVA, and Tukey's post-hoc tests.
Results: The P11-4 group was significantly more effective among the professional-only groups in both parameters (p<0.001). All combined-groups were determined to be statistically more successful than their respective professional-groups in both parameters (p<0.05). Based on lesion depth data, it was observed that the P11-4 and stannous-containing combined-groups showed statistically similar results (p>0.05). In terms of lesion fluorescence data, the P11-4 combined-group was found to be statistically more successful than all other study groups (p<0.05).
Conclusion: The self-assembling peptide P11-4 was determined to exhibit the best preventive and protective anti-erosive effect in both professional and combined applications.
Clinical relevance: A positive relationship was observed between the support of professional applications with home-use daily-dental-care products and protection against erosive lesions.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
