Mónica Alejandra Rosales-Reynoso, Clara Ibet Juárez-Vázquez, Isabel Nohemí García-Sánchez, Alejandra Palacios-Ramírez, Miriam Yadira Godínez-Rodríguez, César de Jesús Tovar-Jácome, Claudia Azucena Tapia-Leyva, Gerardo Emmanuel Robledo-López, José Elías García-Ortiz, Efraín Salas-González, Aldo Antonio Alcaraz-Wong, Martha Patricia Gallegos-Arreola
{"title":"HOTAIR rs12826786、rs920778和rs4759314变异与墨西哥人群乳腺癌易感性和临床病理特征的研究","authors":"Mónica Alejandra Rosales-Reynoso, Clara Ibet Juárez-Vázquez, Isabel Nohemí García-Sánchez, Alejandra Palacios-Ramírez, Miriam Yadira Godínez-Rodríguez, César de Jesús Tovar-Jácome, Claudia Azucena Tapia-Leyva, Gerardo Emmanuel Robledo-López, José Elías García-Ortiz, Efraín Salas-González, Aldo Antonio Alcaraz-Wong, Martha Patricia Gallegos-Arreola","doi":"10.1016/j.clbc.2024.11.021","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) is a multifactorial disease of unknown etiology whose major risk factors are genetic alterations of cell proliferation and migration pathways. HOX transcript antisense RNA gene (HOTAIR) is a long noncoding RNA (lncRNA) related to cell proliferation, progression, invasion, metastasis, and poor survival of multiple cancers, including BC. Controversial results have emerged on the association between breast cancer risk in multiple ethnicities. This study explores the association of rs12826786, rs920778, and rs4759314 variants in the HOTAIR gene in BC patients.</p><p><strong>Methods: </strong>DNA of peripheral blood samples was obtained from 588 women (289 patients and 299 control females). Genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. The association was calculated using the odds ratio (OR) test. p-values were adjusted by the Bonferroni test (0.016).</p><p><strong>Results: </strong>The rs12826786 (C > T), rs920778 (T > C), and rs4759314 (A > G) variants were associated with BC and with TNM stage, histologic type, and histologic molecular subtype (P = .001). Likewise, the haplotype C-T-G in the HOTAIR gene (rs12826786-rs920778-rs4759314) was significantly related to BC (OR = 5.44, 95% CI, 2.22-13.32, P = .001).</p><p><strong>Conclusion: </strong>The results suggest that rs12826786, rs920778, and rs4759314 variants in HOTAIR significantly influence breast cancer risk.</p>","PeriodicalId":10197,"journal":{"name":"Clinical breast cancer","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of HOTAIR rs12826786, rs920778 and rs4759314 Variants With Breast Cancer Susceptibility and Clinicopathological Characteristics in a Mexican Population.\",\"authors\":\"Mónica Alejandra Rosales-Reynoso, Clara Ibet Juárez-Vázquez, Isabel Nohemí García-Sánchez, Alejandra Palacios-Ramírez, Miriam Yadira Godínez-Rodríguez, César de Jesús Tovar-Jácome, Claudia Azucena Tapia-Leyva, Gerardo Emmanuel Robledo-López, José Elías García-Ortiz, Efraín Salas-González, Aldo Antonio Alcaraz-Wong, Martha Patricia Gallegos-Arreola\",\"doi\":\"10.1016/j.clbc.2024.11.021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Breast cancer (BC) is a multifactorial disease of unknown etiology whose major risk factors are genetic alterations of cell proliferation and migration pathways. HOX transcript antisense RNA gene (HOTAIR) is a long noncoding RNA (lncRNA) related to cell proliferation, progression, invasion, metastasis, and poor survival of multiple cancers, including BC. Controversial results have emerged on the association between breast cancer risk in multiple ethnicities. This study explores the association of rs12826786, rs920778, and rs4759314 variants in the HOTAIR gene in BC patients.</p><p><strong>Methods: </strong>DNA of peripheral blood samples was obtained from 588 women (289 patients and 299 control females). Genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. The association was calculated using the odds ratio (OR) test. p-values were adjusted by the Bonferroni test (0.016).</p><p><strong>Results: </strong>The rs12826786 (C > T), rs920778 (T > C), and rs4759314 (A > G) variants were associated with BC and with TNM stage, histologic type, and histologic molecular subtype (P = .001). Likewise, the haplotype C-T-G in the HOTAIR gene (rs12826786-rs920778-rs4759314) was significantly related to BC (OR = 5.44, 95% CI, 2.22-13.32, P = .001).</p><p><strong>Conclusion: </strong>The results suggest that rs12826786, rs920778, and rs4759314 variants in HOTAIR significantly influence breast cancer risk.</p>\",\"PeriodicalId\":10197,\"journal\":{\"name\":\"Clinical breast cancer\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-12-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical breast cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clbc.2024.11.021\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical breast cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.clbc.2024.11.021","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Investigation of HOTAIR rs12826786, rs920778 and rs4759314 Variants With Breast Cancer Susceptibility and Clinicopathological Characteristics in a Mexican Population.
Background: Breast cancer (BC) is a multifactorial disease of unknown etiology whose major risk factors are genetic alterations of cell proliferation and migration pathways. HOX transcript antisense RNA gene (HOTAIR) is a long noncoding RNA (lncRNA) related to cell proliferation, progression, invasion, metastasis, and poor survival of multiple cancers, including BC. Controversial results have emerged on the association between breast cancer risk in multiple ethnicities. This study explores the association of rs12826786, rs920778, and rs4759314 variants in the HOTAIR gene in BC patients.
Methods: DNA of peripheral blood samples was obtained from 588 women (289 patients and 299 control females). Genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. The association was calculated using the odds ratio (OR) test. p-values were adjusted by the Bonferroni test (0.016).
Results: The rs12826786 (C > T), rs920778 (T > C), and rs4759314 (A > G) variants were associated with BC and with TNM stage, histologic type, and histologic molecular subtype (P = .001). Likewise, the haplotype C-T-G in the HOTAIR gene (rs12826786-rs920778-rs4759314) was significantly related to BC (OR = 5.44, 95% CI, 2.22-13.32, P = .001).
Conclusion: The results suggest that rs12826786, rs920778, and rs4759314 variants in HOTAIR significantly influence breast cancer risk.
期刊介绍：
Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.
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