{"title":"奶酪中的脂肪酸通过ABC转运蛋白刺激胆固醇外排。","authors":"Michinori Matsuo, Shiho Takaoka, Kai Nakayama, Akika Nagira, Hirofumi Goto, Akihiro Nakajima","doi":"10.1093/bbb/zbae207","DOIUrl":null,"url":null,"abstract":"<p><p>It is essential to remove cholesterol from the body to suppress atherosclerosis progression. ABCA1 and ABCG1 transport cholesterol in peripheral cells including macrophages and function in the formation of high-density lipoprotein (HDL). ABCG5/ABCG8 functions in the efflux of cholesterol from the body. In this study, we investigated the effects of Camembert cheese extracts and ingredients on cholesterol transport via ABC transporters. Camembert cheese extracts were added to BHK cells expressing ABCA1, ABCG1, or ABCG5/ABCG8, and THP-1 cells expressing ABCA1 and ABCG1. Organic solvent extracts of Camembert cheese increased cholesterol efflux in THP-1 and BHK cells expressing ABCA1 or ABCG5/ABCG8. After fractionation of the extracts, palmitoleic acid was found to increase cholesterol efflux by ABCA1 and ABCG5/ABCG8, whereas 10-hydroxypalmitic acid increased it by ABCA1 and ABCG1. It is suggested that palmitoleic acid and 10-hydroxypalmitic acid in Camembert cheese may prevent the accumulation of excess cholesterol in cells by stimulating ABC transporters.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fatty acids from cheese stimulate cholesterol efflux by ABC transporters.\",\"authors\":\"Michinori Matsuo, Shiho Takaoka, Kai Nakayama, Akika Nagira, Hirofumi Goto, Akihiro Nakajima\",\"doi\":\"10.1093/bbb/zbae207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>It is essential to remove cholesterol from the body to suppress atherosclerosis progression. ABCA1 and ABCG1 transport cholesterol in peripheral cells including macrophages and function in the formation of high-density lipoprotein (HDL). ABCG5/ABCG8 functions in the efflux of cholesterol from the body. In this study, we investigated the effects of Camembert cheese extracts and ingredients on cholesterol transport via ABC transporters. Camembert cheese extracts were added to BHK cells expressing ABCA1, ABCG1, or ABCG5/ABCG8, and THP-1 cells expressing ABCA1 and ABCG1. Organic solvent extracts of Camembert cheese increased cholesterol efflux in THP-1 and BHK cells expressing ABCA1 or ABCG5/ABCG8. After fractionation of the extracts, palmitoleic acid was found to increase cholesterol efflux by ABCA1 and ABCG5/ABCG8, whereas 10-hydroxypalmitic acid increased it by ABCA1 and ABCG1. It is suggested that palmitoleic acid and 10-hydroxypalmitic acid in Camembert cheese may prevent the accumulation of excess cholesterol in cells by stimulating ABC transporters.</p>\",\"PeriodicalId\":9175,\"journal\":{\"name\":\"Bioscience, Biotechnology, and Biochemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-12-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioscience, Biotechnology, and Biochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1093/bbb/zbae207\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience, Biotechnology, and Biochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/bbb/zbae207","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Fatty acids from cheese stimulate cholesterol efflux by ABC transporters.
It is essential to remove cholesterol from the body to suppress atherosclerosis progression. ABCA1 and ABCG1 transport cholesterol in peripheral cells including macrophages and function in the formation of high-density lipoprotein (HDL). ABCG5/ABCG8 functions in the efflux of cholesterol from the body. In this study, we investigated the effects of Camembert cheese extracts and ingredients on cholesterol transport via ABC transporters. Camembert cheese extracts were added to BHK cells expressing ABCA1, ABCG1, or ABCG5/ABCG8, and THP-1 cells expressing ABCA1 and ABCG1. Organic solvent extracts of Camembert cheese increased cholesterol efflux in THP-1 and BHK cells expressing ABCA1 or ABCG5/ABCG8. After fractionation of the extracts, palmitoleic acid was found to increase cholesterol efflux by ABCA1 and ABCG5/ABCG8, whereas 10-hydroxypalmitic acid increased it by ABCA1 and ABCG1. It is suggested that palmitoleic acid and 10-hydroxypalmitic acid in Camembert cheese may prevent the accumulation of excess cholesterol in cells by stimulating ABC transporters.
期刊介绍：
Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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