{"title":"一种基于分层二氧化钛纳米线/微花装饰石墨样氮化碳量子点的“信号开启”光电化学传感器，用于谷胱甘肽检测。","authors":"Romina Rezapour, Majid Arvand, Maryam Farahmand Habibi","doi":"10.1016/j.talanta.2024.127448","DOIUrl":null,"url":null,"abstract":"<p><p>Glutathione (GSH) is a bioactive tripeptide with important physiological functions in animals, plants, and microorganisms. GSH participates in various biochemical reactions in vivo and is known for its antioxidant, anti-allergy, and detoxification properties. This study introduces an innovative photoelectrochemical (PEC) method for GSH detection, leveraging a fluorine-doped tin oxide (FTO) electrode enhanced by TiO<sub>2</sub> nanoflowers and graphitic carbon nitride quantum dots (g-CNQDs). This design formed a type-II heterojunction, which facilitated efficient charge separation and transport. Furthermore, incorporating TiO<sub>2</sub> nanoflowers increases the surface area, while adding g-CNQDs led to a narrowing of the semiconductor bandgap. The fabricated electrode exhibits highly attractive photo-electrocatalytic activity towards GSH detection in neutral media at a low potential bias. The developed PEC sensor demonstrates a wide linear range of 1.0 × 10<sup>-13</sup> to 5 × 10<sup>-5</sup> mol L<sup>-1</sup>, a low detection limit of 5.0 fmol L<sup>-1</sup>, and high sensitivity. These remarkable analytical characteristics highlight the potential of this PEC platform for sensitive and selective GSH detection in various biomedical and environmental applications.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127448"},"PeriodicalIF":5.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A \\\"signal-on\\\" photoelectrochemical sensor based on hierarchical titanium dioxide nanowires/microflowers decorated graphite-like carbon nitride quantum dots for glutathione detection.\",\"authors\":\"Romina Rezapour, Majid Arvand, Maryam Farahmand Habibi\",\"doi\":\"10.1016/j.talanta.2024.127448\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Glutathione (GSH) is a bioactive tripeptide with important physiological functions in animals, plants, and microorganisms. GSH participates in various biochemical reactions in vivo and is known for its antioxidant, anti-allergy, and detoxification properties. This study introduces an innovative photoelectrochemical (PEC) method for GSH detection, leveraging a fluorine-doped tin oxide (FTO) electrode enhanced by TiO<sub>2</sub> nanoflowers and graphitic carbon nitride quantum dots (g-CNQDs). This design formed a type-II heterojunction, which facilitated efficient charge separation and transport. Furthermore, incorporating TiO<sub>2</sub> nanoflowers increases the surface area, while adding g-CNQDs led to a narrowing of the semiconductor bandgap. The fabricated electrode exhibits highly attractive photo-electrocatalytic activity towards GSH detection in neutral media at a low potential bias. The developed PEC sensor demonstrates a wide linear range of 1.0 × 10<sup>-13</sup> to 5 × 10<sup>-5</sup> mol L<sup>-1</sup>, a low detection limit of 5.0 fmol L<sup>-1</sup>, and high sensitivity. These remarkable analytical characteristics highlight the potential of this PEC platform for sensitive and selective GSH detection in various biomedical and environmental applications.</p>\",\"PeriodicalId\":435,\"journal\":{\"name\":\"Talanta\",\"volume\":\"285 \",\"pages\":\"127448\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Talanta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.talanta.2024.127448\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.talanta.2024.127448","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
A "signal-on" photoelectrochemical sensor based on hierarchical titanium dioxide nanowires/microflowers decorated graphite-like carbon nitride quantum dots for glutathione detection.
Glutathione (GSH) is a bioactive tripeptide with important physiological functions in animals, plants, and microorganisms. GSH participates in various biochemical reactions in vivo and is known for its antioxidant, anti-allergy, and detoxification properties. This study introduces an innovative photoelectrochemical (PEC) method for GSH detection, leveraging a fluorine-doped tin oxide (FTO) electrode enhanced by TiO2 nanoflowers and graphitic carbon nitride quantum dots (g-CNQDs). This design formed a type-II heterojunction, which facilitated efficient charge separation and transport. Furthermore, incorporating TiO2 nanoflowers increases the surface area, while adding g-CNQDs led to a narrowing of the semiconductor bandgap. The fabricated electrode exhibits highly attractive photo-electrocatalytic activity towards GSH detection in neutral media at a low potential bias. The developed PEC sensor demonstrates a wide linear range of 1.0 × 10-13 to 5 × 10-5 mol L-1, a low detection limit of 5.0 fmol L-1, and high sensitivity. These remarkable analytical characteristics highlight the potential of this PEC platform for sensitive and selective GSH detection in various biomedical and environmental applications.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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