研究综述：重度抑郁症青少年大脑结构和功能改变的共同和不同——一项多模态荟萃分析

IF 6.5 1区医学 Q1 PSYCHIATRY

Journal of Child Psychology and Psychiatry Pub Date : 2024-12-27 DOI:10.1111/jcpp.14104

Baolin Wu, Xun Zhang, Hongsheng Xie, Baoshuai Zhang, Yanxin Ling, Ruoqiu Gan, Lihua Qiu, Neil Roberts, Zhiyun Jia, Qiyong Gong

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引用次数: 0

摘要

神经影像学研究已经确定了青少年重度抑郁症（MDD）的大脑结构和功能改变；然而，结果并不一致，患者是否表现出空间收敛性结构和功能脑异常仍不清楚。方法：我们分别对基于体素的形态测量（VBM）和静息状态功能研究进行了体素的meta分析，以确定青少年MDD患者的区域灰质体积（GMV）和脑活动改变。进行多模态分析以检查区域GMV和大脑活动改变的重叠。Meta -回归分析评估临床变量的潜在影响。结果纳入了10项全脑VBM研究（403例患者和319例对照）和14项静息状态功能研究（510例患者和474例对照）。青少年MDD患者在左侧前额叶内侧/背外侧皮层、外侧颞叶皮层和感觉运动区以及左侧脑岛表现出联合的结构和功能改变。青春期MDD患者在皮质下和前额叶边缘区表现出结构特异性异常，在右侧脑岛、右侧枕上回、左侧额下回和左侧楔前叶区表现出功能特异性异常。Meta回归分析显示，青少年MDD患者的平均年龄与右颞上回GMV呈正相关，与右脑岛脑活动呈负相关，青少年MDD患者的症状严重程度与右枕上回脑活动呈正相关。结论：该荟萃分析确定了青少年MDD患者联合和分离性脑改变的复杂模式，这可能会促进我们对青少年MDD神经生物学的理解。

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Research Review: Shared and distinct structural and functional brain alterations in adolescents with major depressive disorder' – a multimodal meta‐analysis

BackgroundNeuroimaging studies have identified brain structural and functional alterations in adolescents with major depressive disorder (MDD); however, the results are inconsistent, and whether patients exhibit spatially convergent structural and functional brain abnormalities remains unclear.MethodsWe conducted voxel‐wise meta‐analysis of voxel‐based morphometry (VBM) and resting‐state functional studies, respectively, to identify regional gray matter volume (GMV) and brain activity alterations in adolescent MDD patients. Multimodal analysis was performed to examine the overlap of regional GMV and brain activity alterations. Meta‐regression analysis was conducted to evaluate the potential effects of clinical variables.ResultsTen whole‐brain VBM studies (403 patients and 319 controls) and 14 resting‐state functional studies (510 patients and 474 controls) were included. Adolescent MDD patients showed conjoint structural and functional alterations in the left medial/dorsolateral prefrontal cortex, lateral temporal cortex and sensorimotor regions, and left insula. Adolescent MDD patients showed structural‐specific abnormalities in the subcortical and prefrontal‐limbic regions and functional‐specific abnormalities in the right insula, right superior occipital gyrus, left inferior frontal gyrus and left precuneus. Meta‐regression analyses revealed that the mean age of adolescents with MDD was positively associated with GMV in the right superior temporal gyrus and negatively associated with brain activity in the right insula, and the symptom severity of adolescents with MDD was positively associated with brain activity in the right superior occipital gyrus.ConclusionsThis meta‐analysis identified complicated patterns of conjoint and dissociated brain alterations in adolescent MDD patients, which may advance our understanding of the neurobiology of adolescent MDD.

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来源期刊

Journal of Child Psychology and Psychiatry 医学-精神病学

CiteScore

13.80

自引率

5.30%

发文量

169

审稿时长

1 months

期刊介绍： The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.