雄性白化大鼠的亚急性潜在危险

IF 4.4 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology Pub Date : 2024-12-28 DOI:10.1002/tox.24462

Maher S. Salama, Khaled A. Osman, Rania Elbanna

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引用次数: 0

摘要

本研究旨在研究连续14天口服0.031或0.31 mg/kg/天的恶氨酰对雄性白化大鼠的亚急性影响。研究结果表明，oxamyl对大多数检查的血液特征和生物标志物产生了显著影响，同时在器官组织学中产生了显著的进行性和可识别的改变。根据研究结果，通过组织病理学检查确定了恶氨酰对大鼠毒性作用的潜在机制为：恶氨酰处理后的炎症指标、对转氨酶、碱性磷酸酶和抗氧化酶的抑制以及器官中硫代巴比妥酸反应物质（tbar）的产生。由于大鼠和人类之间的大量遗传相似性，因此预计oxamyl将对人类产生类似的有害影响。

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The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats

The current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration of either 0.031 or 0.31 mg/kg/day for 14 consecutive days. The findings demonstrated that oxamyl produced a significant impact on most of the examined blood profile and biomarkers, along with a significant progressive and discernible alterations in the histology of organs. According to the results obtained, the potential mechanisms by which oxamyl causes its toxic effects on rats are identified as the inflammation indices, the inhibition of transaminases, alkaline phosphatase, and antioxidant enzymes, as well as the production of thiobarbituric acid reactive substances (TBARs) in organs following oxamyl treatment based on histopathological examinations. Due to the substantial genetic similarities between rats and humans, it is therefore anticipated that oxamyl will have comparable detrimental effects on humans.

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来源期刊

Environmental Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

8.90%

发文量

261

审稿时长

4.5 months

期刊介绍： The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are: Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration; Natural toxins and their impacts; Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation; Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard; Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.