WNT空间激活紊乱——系统性硬化症（SSc）网状皮肤表型的潜在驱动因素

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-12-25 DOI:10.1002/art.43094

Sara Chenguiti Fakhouri, Honglin Zhu, Yi-Nan Li, Moritz Ronicke, Aleix Rius Rigau, Clara Dees, Laura Konstantinidis, Ralf Schmid, Alexandru-Emil Matei, Markus Eckstein, Carol Geppert, Ingo Ludolph, Alexander Kreuter, Michael Sticherling, Carola Berking, Raymund E. Horch, Georg Schett, Jörg H.W. Distler, Christina Bergmann

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引用次数: 0

摘要

对于维持成人皮肤完整的生理机制，我们所知甚少。本研究旨在定量描述与对照组相比，系统性硬化症（SSc）皮肤的解剖学变化，并探讨其潜在机制。

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Disturbed spatial WNT activation – a potential driver of the reticularized skin phenotype in Systemic Sclerosis (SSc)

Little is known on the mechanisms necessary to maintain the physiological adult human skin integrity. This study aims to quantitatively describe anatomical changes in systemic sclerosis (SSc)-skin compared to controls and investigate the underlying mechanisms.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.