硅烷促进硫苯肼与二氧化碳对1,3,4-噻二唑-2(3H)- 1的环加成反应

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-12-20 DOI:10.1039/d4cc06242f

Hailong Chen , Junhang Gao , Yang Zhao , Junhao Peng , Xinyang Jiang , Zhenlian Wang , Jiang Cheng

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引用次数: 0

摘要

在此，我们开发了一种硅烷促进的硫苯肼与二氧化碳的环加成反应，得到1,3,4-噻二唑-2(3H)-酮。这个过程进行顺序的n -硅基化，二氧化碳固定到肼甲酰中间体，然后是分子内亲核环化和芳构化。一系列的官能团在这个过程中耐受良好。因此，它代表了利用二氧化碳构建增值杂环框架的一种简单有效的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Silane-promoted cycloaddition of thiobenzhydrazides with carbon dioxide toward 1,3,4-thiadiazol-2(3H)-ones†

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Silane-promoted cycloaddition of thiobenzhydrazides with carbon dioxide toward 1,3,4-thiadiazol-2(3H)-ones†

Herein, we developed a silane-promoted cycloaddition of thiobenzhydrazides with carbon dioxide leading to 1,3,4-thiadiazol-2(3H)-ones. This procedure involves sequential N-silylation and fixation of carbon dioxide toward a hydrazine formyl intermediate, followed by intramolecular nucleophilic cyclization and aromatization. A series of functional groups are well-tolerated under this procedure. As such, it represents a facile and efficient pathway for utilizing carbon dioxide in the construction of value-added heterocyclic frameworks.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.