产ctx - m -8大肠杆菌的国际克隆对巴西亚马逊半水生海龟肠道定植的影响。

IF 2.4 2区农林科学 Q3 MICROBIOLOGY

Veterinary microbiology Pub Date : 2025-02-01 DOI:10.1016/j.vetmic.2024.110344

Meire Maria da Silva , Fábio Parra Sellera , João Pedro Rueda Furlan , Valentina Aravena-Ramírez , Danny Fuentes-Castillo , Bruna Fuga , Alexandre José dos Santos Fróes , Alana Lislea de Sousa , Felício Garino Junior , Nilton Lincopan

{"title":"产ctx - m -8大肠杆菌的国际克隆对巴西亚马逊半水生海龟肠道定植的影响。","authors":"Meire Maria da Silva , Fábio Parra Sellera , João Pedro Rueda Furlan , Valentina Aravena-Ramírez , Danny Fuentes-Castillo , Bruna Fuga , Alexandre José dos Santos Fróes , Alana Lislea de Sousa , Felício Garino Junior , Nilton Lincopan","doi":"10.1016/j.vetmic.2024.110344","DOIUrl":null,"url":null,"abstract":"<div><div>Extended-spectrum β-lactamase (ESBL)-producing <em>Escherichia coli</em> poses a significant threat to public health due to its ability to confer resistance to broad-spectrum antimicrobials, especially third-generation cephalosporins. Herein, we report gut colonization by international clones of CTX-M-8-producing <em>E. coli</em> in scorpion mud turtles (<em>Kinosternon scorpioides</em>) from a captive breeding program in the Brazilian Amazon. The <em>E. coli</em> strains exhibited multidrug resistance to clinically relevant antimicrobials, and genomic analyses revealed broad resistomes to antimicrobials, heavy metals, pesticides, and disinfectants. Detecting these medically important bacteria in captive wildlife underscores the potential risks associated with reintroduction programs, as ESBL-producing bacteria may spill over into the natural ecosystem and threaten wildlife. Our findings highlight the need for enhanced surveillance and control measures in wildlife conservation programs to mitigate the risks of antimicrobial resistance transmission between captive and wild populations.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"301 ","pages":"Article 110344"},"PeriodicalIF":2.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gut colonization of semi-aquatic turtles inhabiting the Brazilian Amazon by international clones of CTX-M-8-producing Escherichia coli\",\"authors\":\"Meire Maria da Silva , Fábio Parra Sellera , João Pedro Rueda Furlan , Valentina Aravena-Ramírez , Danny Fuentes-Castillo , Bruna Fuga , Alexandre José dos Santos Fróes , Alana Lislea de Sousa , Felício Garino Junior , Nilton Lincopan\",\"doi\":\"10.1016/j.vetmic.2024.110344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Extended-spectrum β-lactamase (ESBL)-producing <em>Escherichia coli</em> poses a significant threat to public health due to its ability to confer resistance to broad-spectrum antimicrobials, especially third-generation cephalosporins. Herein, we report gut colonization by international clones of CTX-M-8-producing <em>E. coli</em> in scorpion mud turtles (<em>Kinosternon scorpioides</em>) from a captive breeding program in the Brazilian Amazon. The <em>E. coli</em> strains exhibited multidrug resistance to clinically relevant antimicrobials, and genomic analyses revealed broad resistomes to antimicrobials, heavy metals, pesticides, and disinfectants. Detecting these medically important bacteria in captive wildlife underscores the potential risks associated with reintroduction programs, as ESBL-producing bacteria may spill over into the natural ecosystem and threaten wildlife. Our findings highlight the need for enhanced surveillance and control measures in wildlife conservation programs to mitigate the risks of antimicrobial resistance transmission between captive and wild populations.</div></div>\",\"PeriodicalId\":23551,\"journal\":{\"name\":\"Veterinary microbiology\",\"volume\":\"301 \",\"pages\":\"Article 110344\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary microbiology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0378113524003663\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary microbiology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378113524003663","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

产广谱β-内酰胺酶（ESBL）的大肠杆菌能够对广谱抗菌素，特别是第三代头孢菌素产生耐药性，对公众健康构成重大威胁。在此，我们报告了产ctx - m -8大肠杆菌的国际克隆在巴西亚马逊圈养繁殖计划的蝎泥龟（Kinosternon scorpioides）的肠道定植。大肠杆菌菌株对临床相关的抗菌素表现出多重耐药性，基因组分析显示对抗菌素、重金属、杀虫剂和消毒剂具有广泛的抗性。在圈养野生动物身上检测到这些医学上重要的细菌，强调了与放归计划相关的潜在风险，因为产生esbl的细菌可能会溢出到自然生态系统中，威胁野生动物。我们的研究结果强调了在野生动物保护计划中加强监测和控制措施的必要性，以减轻圈养种群和野生种群之间抗菌素耐药性传播的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Gut colonization of semi-aquatic turtles inhabiting the Brazilian Amazon by international clones of CTX-M-8-producing Escherichia coli

Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli poses a significant threat to public health due to its ability to confer resistance to broad-spectrum antimicrobials, especially third-generation cephalosporins. Herein, we report gut colonization by international clones of CTX-M-8-producing E. coli in scorpion mud turtles (Kinosternon scorpioides) from a captive breeding program in the Brazilian Amazon. The E. coli strains exhibited multidrug resistance to clinically relevant antimicrobials, and genomic analyses revealed broad resistomes to antimicrobials, heavy metals, pesticides, and disinfectants. Detecting these medically important bacteria in captive wildlife underscores the potential risks associated with reintroduction programs, as ESBL-producing bacteria may spill over into the natural ecosystem and threaten wildlife. Our findings highlight the need for enhanced surveillance and control measures in wildlife conservation programs to mitigate the risks of antimicrobial resistance transmission between captive and wild populations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Veterinary microbiology 农林科学-兽医学

CiteScore

5.90

自引率

6.10%

发文量

221

审稿时长

52 days

期刊介绍： Veterinary Microbiology is concerned with microbial (bacterial, fungal, viral) diseases of domesticated vertebrate animals (livestock, companion animals, fur-bearing animals, game, poultry, fish) that supply food, other useful products or companionship. In addition, Microbial diseases of wild animals living in captivity, or as members of the feral fauna will also be considered if the infections are of interest because of their interrelation with humans (zoonoses) and/or domestic animals. Studies of antimicrobial resistance are also included, provided that the results represent a substantial advance in knowledge. Authors are strongly encouraged to read - prior to submission - the Editorials (''Scope or cope'' and ''Scope or cope II'') published previously in the journal. The Editors reserve the right to suggest submission to another journal for those papers which they feel would be more appropriate for consideration by that journal. Original research papers of high quality and novelty on aspects of control, host response, molecular biology, pathogenesis, prevention, and treatment of microbial diseases of animals are published. Papers dealing primarily with immunology, epidemiology, molecular biology and antiviral or microbial agents will only be considered if they demonstrate a clear impact on a disease. Papers focusing solely on diagnostic techniques (such as another PCR protocol or ELISA) will not be published - focus should be on a microorganism and not on a particular technique. Papers only reporting microbial sequences, transcriptomics data, or proteomics data will not be considered unless the results represent a substantial advance in knowledge. Drug trial papers will be considered if they have general application or significance. Papers on the identification of microorganisms will also be considered, but detailed taxonomic studies do not fall within the scope of the journal. Case reports will not be published, unless they have general application or contain novel aspects. Papers of geographically limited interest, which repeat what had been established elsewhere will not be considered. The readership of the journal is global.