杜拉鲁肽治疗糖尿病降低肝脏脂肪含量:一项双中心、单组开放试验。

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM
Chuanfeng Liu, Yu Xin, Yajing Huang, Lili Xu, Ruizhi Zhou, Yangang Wang, Wei Wang
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引用次数: 0

摘要

背景:随着NAFLD患病率水平的升高,糖尿病、高血压、代谢综合征等疾病的发病率也显著升高。GLP-1RA具有减肥、降血糖和多种非降糖作用。然而,GLP-1RA定量降低肝脏脂肪含量与改善胰岛功能之间的关系尚不清楚。方法:本试验为单组开放队列研究。GLP-1RA治疗组共纳入38例T2DM和NAFLD患者。对纳入的患者进行生化和血糖水平、脂联素和FGF21水平检测,并使用MRI测量肝脏脂肪含量。GLP-1RA治疗至少3个月后再次测量上述指标。根据肝脏脂肪含量降低程度分为Q1组(平均降低0.37%)和Q2组(平均降低8.6%)。结果:Q2组肝脏脂肪含量平均下降8.6%,糖化血红蛋白下降18.17%,体重减轻7.29%,空腹c肽释放增加1.03%,餐后1小时和2小时c肽释放分别增加28.86%和18.28%。相比之下,Q1组肝脏脂肪含量平均下降0.37%,糖化血红蛋白仅下降6.53%,体重减轻3.41%,空腹c肽释放减少1.91%,餐后1小时和2小时c肽释放分别增加19.18%和11.66%。结论:降低肝脏脂肪含量可有效改善胰岛功能分泌,尤其是餐后c肽分泌,尤其是餐后1小时内的分泌。这种改善导致糖化血红蛋白水平的降低,并促进更好地遵守血糖控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial

Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial

Background

With the elevated level of NAFLD prevalence, the incidence of diabetes, hypertension, metabolic syndrome and other diseases is also significantly elevated. GLP-1RA can exert weight loss, glucose-lowering effects and various nonglycaemic effects. However, the relationship between quantitative reduction in hepatic fat content and improvement of pancreatic islet function by GLP-1RA is unclear.

Methods

This trial was a single-arm open cohort study. A total of 38 patients with T2DM and NAFLD were enrolled in the GLP-1RA treatment group. The included patients were tested for biochemical and blood glucose levels, adiponectin and FGF21 levels, and liver fat content was measured using MRI. Measure the above indicators again after at least 3 months of GLP-1RA treatment. Divided into Q1 (average decrease of 0.37%) and Q2 (average decrease of 8.6%) groups based on the degree of reduction in liver fat content.

Results

Q2 group showed an average reduction in liver fat content of 8.6%, a decrease in glycated haemoglobin of 18.17%, a weight loss of 7.29% and an increase in fasting c-peptide release by 1.03%, 1-h and 2-h postprandial c-peptide release by 28.86% and 18.28% respectively. In contrast, Q1 group had an average reduction in liver fat content of 0.37%, a decrease in glycated haemoglobin of only 6.53%, a weight loss of 3.41%, a decrease in fasting c-peptide release by 1.91% and an increase in 1-h and 2-h postprandial c-peptide release by 19.18% and 11.66% respectively.

Conclusion

Reduction in liver fat content effectively improves pancreatic islet function secretion, particularly postprandial c-peptide secretion, especially in the first hour after a meal. This improvement leads to a decrease in glycated haemoglobin levels and promotes better compliance with blood glucose control.

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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
自引率
0.00%
发文量
66
审稿时长
6 weeks
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