提高年轻男性HBV感染患者对移动医疗平台定期随访的依从性，可能具有降低晚期肝癌发病率的成本效益。

IF 2 3区医学 Q2 MEDICINE, GENERAL & INTERNAL

Patient preference and adherence Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.2147/PPA.S497831

Hao Liang, Min Yang, Dan Luo, Ya-Kun Wu

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引用次数: 0

摘要

背景：年轻人对社会经济做出了巨大贡献。然而，最近年轻人患肝癌的人数有所增加。此外，这些病人的死亡率很高。方法：回顾性分析12年来年轻肝癌患者的危险因素。结果：男性、HBV感染、家族史等肝癌危险因素在年轻患者中较为常见。近80%的年轻患者（198/253）检测为HBsAg阳性。然而，这些患者中的大多数并没有按照建议定期去看医生。因此，55.7%的年轻患者被诊断为晚期肝癌。在多变量logistic回归中，天冬氨酸转氨酶（AST）水平与晚期肝癌独立相关（OR = 4.262, 95% CI = 1.559-11.65, P = 0.005）。1年生存率为19.4%。结论：青年肝癌高危因素普遍存在。年轻患者对定期就诊的依从性差可能是晚期肝癌比例高的原因之一。这些患者的1年生存率很低。通过移动医疗平台提高患者的依从性和监测血清AST水平可能降低年轻人肝癌的发病率和死亡率。

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Improving Adherence of Young Male Patients with HBV Infection to the Regular Follow-Up via Mobile Healthcare Platform Might Be Cost-Effective to Decrease the Morbidity of Advanced Liver Cancer.

Background: Young adults contribute substantially to the social economy. However, the number of young adults with liver cancer has increased recently. In addition, the mortality rate of these patients is high.

Methods: This retrospective study investigated the risk factors of young patients diagnosed with liver cancer over the past 12 years.

Results: The risk factors of liver cancer, including male, HBV infection, and family history of diseases, were more common in young patients. Nearly 80% of young patients (198/253) were tested as positive HBsAg. However, most of these patients did not visit doctors regularly, as recommended. Thus, 55.7% of young patients were diagnosed with advanced liver cancer. The aspartate aminotransferase (AST) levels were independently associated with advanced liver cancer (OR = 4.262, 95% CI = 1.559-11.65, P = 0.005) in the multivariable logistic regression. The 1-year survival rate of these patients was 19.4%.

Conclusion: The high-risk factors of liver cancer are common in young patients. The poor adherence to regularly visited doctors in young patients might contribute to the high ratio of advanced liver cancer. The 1-year survival rate of these patients is low. Improving patient's adherence via mobile healthcare platform and monitoring serum AST levels might decrease the incidence and mortality of liver cancer in young adults.

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来源期刊

Patient preference and adherence MEDICINE, GENERAL & INTERNAL-

CiteScore

3.60

自引率

4.50%

发文量

354

审稿时长

6-12 weeks

期刊介绍： Patient Preference and Adherence is an international, peer reviewed, open access journal that focuses on the growing importance of patient preference and adherence throughout the therapeutic continuum. The journal is characterized by the rapid reporting of reviews, original research, modeling and clinical studies across all therapeutic areas. Patient satisfaction, acceptability, quality of life, compliance, persistence and their role in developing new therapeutic modalities and compounds to optimize clinical outcomes for existing disease states are major areas of interest for the journal. As of 1st April 2019, Patient Preference and Adherence will no longer consider meta-analyses for publication.