四边形单元草的细胞毒性孕酮苷。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-24 DOI:10.1080/14786419.2024.2445199

Ghada A Ismail, Mohamed E Mostafa, Ahmed Y Mubarak, AbelAziz M Dawidar, Mamdouh Abdel-Mogib

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引用次数: 0

摘要

四角单叶麻是夹竹桃科的一种药用多肉植物。通过植物化学检测，分离出3个独特的新孕烷苷，quadrangulosides G-I(1-3)，并利用1D、2D NMR和ESI MS对其结构进行了分析。采用MTT法，以阿霉素为阳性对照，研究了从四棱草中分离得到的16种孕苷对乳腺癌细胞株（MCF-7）和结肠癌细胞株（HCT-116）的细胞毒性。其中russelioside B和quadranguloside E的IC50值分别为0.18、0.22 μM和0.56、0.12 μM，细胞毒作用最强。

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Cytotoxic pregnane glycosides from Monolluma quadrangula (Forssk.).

Monolluma quadrangula (Forssk.) is a medicinal succulent plant belonging to the family Apocynaceae. The phytochemical examination of M. quadrangula methanolic extract resulted in isolation of three unique new pregnane glycosides, quadrangulosides G-I (1-3), their structures were elucidated utilising 1D, 2D NMR and ESI MS spectral studies. Pure sixteen isolated pregnane glycosides from M. quadrangula were tested for cytotoxicity against breast cancer cell lines (MCF-7) and colon cancer cell lines (HCT-116), using MTT assay and doxorubicin as a positive control. From these compounds russelioside B and quadranguloside E displayed the most potent cytotoxic effect with IC₅₀ values of 0.18, 0.22 μM and 0.56 and 0.12 μM, respectively.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.