轻度系膜增生性IgA肾病患者经trf -布地奈德治疗后糖皮质激素依赖性肾病综合征完全缓解1例。

IF 2.3 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephron Pub Date : 2024-12-23 DOI:10.1159/000543271

Efstathios Mitsopoulos, Panagiotis Pateinakis, Christodoulos Keskinis, Dorothea Papadopoulou

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引用次数: 0

摘要

肾病综合征合并IgA肾病的轻度组织病理学病变被一些人认为是IgA肾病合并叠加最小改变病（MCD）的一种特殊形式，而另一些人则认为是MCD患者IgA的巧合沉积（MCD- igan）。我们报告了第一例肾病综合征完全缓解的55岁男性MCD-IgAN患者，在给予布地奈德靶向释放制剂（trf -布地奈德）后。尽管之前已经尝试过甲基强的松龙、霉酚酸酯和环磷酰胺，但患者使用trf -布地奈德治疗是特别重要的，因为它不仅表明trf -布地奈德似乎是MCD-IgAN的一种有希望的治疗方法，而且可能为足细胞病变患者提供一种新的治疗选择。

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A case of complete remission of glucocorticoid-dependent nephrotic syndrome after TRF-budesonide treatment in a patient with mild mesangial proliferative IgA nephropathy.

The combination of nephrotic syndrome with mild histopathological lesions of IgA nephropathy is considered by some as a special form of IgA nephropathy with superimposed minimal change disease (MCD) while by others as coincidental deposition of IgA in patients with MCD (MCD-IgAN). We present the first case of complete remission of nephrotic syndrome in a 55-year-old man with MCD-IgAN after the administration of targeted-release formulation of budesonide (TRF-budesonide). The patient's treatment with TRF-budesonide, even though methylprednisolone, mycophenolate mofetil, and cyclophosphamide had been previously tried, is of particular importance because it not only suggests that TRF-budesonide appears to be a promising treatment for MCD-IgAN but may also provide a new therapeutic option for patients with podocytopathies.

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来源期刊

Nephron UROLOGY & NEPHROLOGY-

CiteScore

5.00

自引率

0.00%

发文量

期刊介绍： ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.