{"title":"美国妇女饮食中烟酸摄入量与类风湿关节炎的关系：一项基于国家健康和营养检查调查数据库的研究。","authors":"Xuelian Hong, Fengfeng Jiang","doi":"10.2147/IJWH.S482294","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the association between dietary niacin intake and rheumatoid arthritis (RA) in American women through the National Health and Nutrition Examination Survey (NHANES) database.</p><p><strong>Methods: </strong>A retrospective analysis was conducted based on NHANES 2003-2016 data. Dietary niacin intake was stratified using weighted quartiles and association of dietary niacin intake with RA was explored using weighted logistic regression models and restricted cubic splines (RCS). Subgroup analysis was conducted, adjusting for all confounding factors, and a likelihood ratio test was utilized to determine significant covariates for the interaction term. Stratified analysis was conducted on significant covariates to determine their impact on the association of dietary niacin intake with RA.</p><p><strong>Results: </strong>Fourteen thousand five hundred and thirty-nine American women were selected according to inclusion and exclusion criteria, among whom 845 (4.4%) had RA. Compared with American women without RA, American women with RA had significantly lower dietary niacin intake (18.90 vs 21.22, <i>P</i><0.001). Logistic regression models and RCS analysis reported a significant linear negative correlation between dietary niacin intake and prevalence of RA (Odds Ratio (OR) < 1, <i>P</i> < 0.05, <i>P</i>-non-linear >0.05). The interaction-term <i>P</i>-values showed that this association was significantly influenced by poverty income ratio (PIR), education level, Body Mass Index (BMI), and smoking (<i>P</i> for interaction < 0.05). Stratified analysis unveiled that this association was particularly significant in individuals aged ≥ 40 years (OR: 0.98, 95% Confidence Interval (CI): 0.97-0.99, <i>P</i> < 0.05), PIR > 3.5 (OR: 0.96, 95% CI: 0.93-0.99, <i>P</i> < 0.05), with a college education or higher (OR: 0.97, 95% CI: 0.94-0.99, <i>P</i> < 0.01), BMI ≥ 30kg/m² (OR: 0.98, 95% CI: 0.96-0.99, <i>P</i> < 0.05), non-smokers (OR: 0.97, 95% CI: 0.95-0.99, <i>P</i> < 0.01), or former smokers (OR: 0.95, 95% CI: 0.95-0.99, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Increased dietary niacin intake was associated with a reduced prevalence of RA, especially in women aged ≥40, PIR > 3.5, with at least a college education, BMI ≥ 30kg/m², and currently non-smokers.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"16 ","pages":"2209-2219"},"PeriodicalIF":2.5000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665156/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association Between Dietary Niacin Intake and Rheumatoid Arthritis in American Women: A Study Based on National Health and Nutrition Examination Survey Database.\",\"authors\":\"Xuelian Hong, Fengfeng Jiang\",\"doi\":\"10.2147/IJWH.S482294\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to explore the association between dietary niacin intake and rheumatoid arthritis (RA) in American women through the National Health and Nutrition Examination Survey (NHANES) database.</p><p><strong>Methods: </strong>A retrospective analysis was conducted based on NHANES 2003-2016 data. Dietary niacin intake was stratified using weighted quartiles and association of dietary niacin intake with RA was explored using weighted logistic regression models and restricted cubic splines (RCS). Subgroup analysis was conducted, adjusting for all confounding factors, and a likelihood ratio test was utilized to determine significant covariates for the interaction term. Stratified analysis was conducted on significant covariates to determine their impact on the association of dietary niacin intake with RA.</p><p><strong>Results: </strong>Fourteen thousand five hundred and thirty-nine American women were selected according to inclusion and exclusion criteria, among whom 845 (4.4%) had RA. Compared with American women without RA, American women with RA had significantly lower dietary niacin intake (18.90 vs 21.22, <i>P</i><0.001). Logistic regression models and RCS analysis reported a significant linear negative correlation between dietary niacin intake and prevalence of RA (Odds Ratio (OR) < 1, <i>P</i> < 0.05, <i>P</i>-non-linear >0.05). The interaction-term <i>P</i>-values showed that this association was significantly influenced by poverty income ratio (PIR), education level, Body Mass Index (BMI), and smoking (<i>P</i> for interaction < 0.05). Stratified analysis unveiled that this association was particularly significant in individuals aged ≥ 40 years (OR: 0.98, 95% Confidence Interval (CI): 0.97-0.99, <i>P</i> < 0.05), PIR > 3.5 (OR: 0.96, 95% CI: 0.93-0.99, <i>P</i> < 0.05), with a college education or higher (OR: 0.97, 95% CI: 0.94-0.99, <i>P</i> < 0.01), BMI ≥ 30kg/m² (OR: 0.98, 95% CI: 0.96-0.99, <i>P</i> < 0.05), non-smokers (OR: 0.97, 95% CI: 0.95-0.99, <i>P</i> < 0.01), or former smokers (OR: 0.95, 95% CI: 0.95-0.99, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Increased dietary niacin intake was associated with a reduced prevalence of RA, especially in women aged ≥40, PIR > 3.5, with at least a college education, BMI ≥ 30kg/m², and currently non-smokers.</p>\",\"PeriodicalId\":14356,\"journal\":{\"name\":\"International Journal of Women's Health\",\"volume\":\"16 \",\"pages\":\"2209-2219\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-12-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665156/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Women's Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJWH.S482294\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S482294","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究旨在通过美国国家健康与营养调查（NHANES）数据库，探讨饮食中烟酸摄入量与美国女性类风湿关节炎（RA）之间的关系。方法：对2003-2016年NHANES数据进行回顾性分析。采用加权四分位数对饮食中烟酸摄入量进行分层，并利用加权logistic回归模型和限制性三次样条（RCS）探讨饮食中烟酸摄入量与RA的关系。进行亚组分析，调整所有混杂因素，并利用似然比检验确定交互项的显著协变量。对显著协变量进行分层分析，以确定它们对饮食烟酸摄入量与RA之间关系的影响。结果：根据纳入和排除标准选择了14539名美国妇女，其中845名（4.4%）患有RA。与非RA的美国女性相比，RA的美国女性饮食中烟酸摄入量显著降低（18.90 vs 21.22, PP < 0.05， p -非线性>0.05）。交互项P值显示，贫困收入比（PIR）、教育水平、身体质量指数（BMI）和吸烟显著影响这种关联（交互项P < 0.05）。分层分析公布了这个协会是特别重要的个人≥40岁(OR: 0.98, 95%可信区间(CI): 0.97 - -0.99, P < 0.05), PIR > 3.5 (OR: 0.96, 95%置信区间CI: 0.93 - -0.99, P < 0.05),与大学教育或更高(OR: 0.97, 95%置信区间CI: 0.94 - -0.99, P < 0.01),体重指数≥30公斤/ m²(OR: 0.98, 95%置信区间CI: 0.96 - -0.99, P < 0.05),非吸烟者(OR: 0.97, 95%置信区间CI: 0.95 - -0.99, P < 0.01),或前吸烟者(OR: 0.95, 95%置信区间CI: 0.95 - -0.99, P < 0.05)。结论：饮食中烟酸摄入量的增加与RA患病率的降低有关，尤其是在年龄≥40岁、PIR bbb3.5、至少受过大学教育、BMI≥30kg/m²、目前不吸烟的女性中。
Association Between Dietary Niacin Intake and Rheumatoid Arthritis in American Women: A Study Based on National Health and Nutrition Examination Survey Database.
Objective: This study aimed to explore the association between dietary niacin intake and rheumatoid arthritis (RA) in American women through the National Health and Nutrition Examination Survey (NHANES) database.
Methods: A retrospective analysis was conducted based on NHANES 2003-2016 data. Dietary niacin intake was stratified using weighted quartiles and association of dietary niacin intake with RA was explored using weighted logistic regression models and restricted cubic splines (RCS). Subgroup analysis was conducted, adjusting for all confounding factors, and a likelihood ratio test was utilized to determine significant covariates for the interaction term. Stratified analysis was conducted on significant covariates to determine their impact on the association of dietary niacin intake with RA.
Results: Fourteen thousand five hundred and thirty-nine American women were selected according to inclusion and exclusion criteria, among whom 845 (4.4%) had RA. Compared with American women without RA, American women with RA had significantly lower dietary niacin intake (18.90 vs 21.22, P<0.001). Logistic regression models and RCS analysis reported a significant linear negative correlation between dietary niacin intake and prevalence of RA (Odds Ratio (OR) < 1, P < 0.05, P-non-linear >0.05). The interaction-term P-values showed that this association was significantly influenced by poverty income ratio (PIR), education level, Body Mass Index (BMI), and smoking (P for interaction < 0.05). Stratified analysis unveiled that this association was particularly significant in individuals aged ≥ 40 years (OR: 0.98, 95% Confidence Interval (CI): 0.97-0.99, P < 0.05), PIR > 3.5 (OR: 0.96, 95% CI: 0.93-0.99, P < 0.05), with a college education or higher (OR: 0.97, 95% CI: 0.94-0.99, P < 0.01), BMI ≥ 30kg/m² (OR: 0.98, 95% CI: 0.96-0.99, P < 0.05), non-smokers (OR: 0.97, 95% CI: 0.95-0.99, P < 0.01), or former smokers (OR: 0.95, 95% CI: 0.95-0.99, P < 0.05).
Conclusion: Increased dietary niacin intake was associated with a reduced prevalence of RA, especially in women aged ≥40, PIR > 3.5, with at least a college education, BMI ≥ 30kg/m², and currently non-smokers.
期刊介绍：
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
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