间苯三酚对反复植入失败患者冷冻胚胎移植后子宫蠕动的影响：一项回顾性病例对照研究。

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-02-01 DOI:10.1016/j.ejogrb.2024.12.026

Wei-wei Ma, Ting-ting Li, Jing Li

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引用次数: 0

摘要

目的：回顾性探讨冻融胚胎移植后间苯三酚对复发性胚胎植入失败（RIF）患者的疗效。材料与方法：139对经历RIF并进行体外受精和胚胎移植的不育夫妇分为对照组（n = 66）和间苯三酚组（n = 73）。间苯三酚组的妇女在胚胎移植后30分钟接受80毫克间苯三酚，然后每天一次，直到胚胎移植后第3天。对照组不使用间苯三酚。结果：与对照组相比，间苯三酚组妊娠试验阳性率（52.1% vs 30.3%）、临床妊娠率（45.2% vs 27.3%）和活产率（38.4% vs 21.2%）显著升高(p)。结论：结果表明，冷冻胚胎移植后给予间苯三酚可改善RIF患者的妊娠结局，主要是那些有子宫肠膨出3波/分钟的患者。

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Effects of phloroglucinol on uterine peristalsis after frozen embryo transfer in patients experiencing recurrent implantation failure: A retrospective case-control study

Objective

To retrospectively investigate the efficacy of phloroglucinol administration after freeze-thawed embryo transfer in patients experiencing recurrent implantation failure (RIF).

Materials and Methods

A total of 139 infertile couples who experienced RIF undergoing in vitro fertilisation and embryo transfer were divided into the control (n = 66) and the phloroglucinol (n = 73) groups. Women in the phloroglucinol group received 80 mg phloroglucinol 30 min after transfer, then once daily up to day 3 after the embryo transfer. Those in the control group did not receive phloroglucinol.

Results

Administration of phloroglucinol was associated with significantly higher rates of positive pregnancy tests [52.1 % versus (vs) 30.3 %], clinical pregnancy (45.2 % vs 27.3 %), and live births (38.4 % vs 21.2 %) compared with the control group (p < 0.05). Notably, patients with uterine peristalsis exceeding 3 waves/min exhibited significant improvement in positive pregnancy tests (67.6 % vs 38.5 %), implantation (50 % vs 24.6 %), and clinical pregnancy rates (58.8 % vs 33.3 %) following phloroglucinol intervention (p < 0.05).

Conclusion

Results suggested that the administration of phloroglucinol after frozen embryo transfer may improve pregnancy outcomes in patients who experienced RIF, primarily in those with uterine peristalsis >3 waves/min.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.