马兴益肝方通过调节骨关节炎软骨细胞自噬促进软骨再生。

IF 1.5 4区生物学 Q4 CELL BIOLOGY

In Vitro Cellular & Developmental Biology. Animal Pub Date : 2024-12-24 DOI:10.1007/s11626-024-01006-x

Liqin Zhang, Guangping Zheng, Weicheng Zhao, Chun He, Zhongming Huang

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引用次数: 0

摘要

麻风益肝方（MYF）是中国几十年来用于治疗OA的传统中药处方。然而，其机制尚不清楚。在这项研究中，我们开发了myf -胶原海绵（MYF@CS），并研究了其软骨再生效果和潜在机制。体外实验显示，MYF显著促进OA软骨细胞的细胞活力、增殖和自噬。此外，通过宏观观察、国际软骨修复学会（ICRS）视觉组织学评分和组织学检查，MYF@CS显著促进软骨发生和软骨再生。我们的研究结果表明MYF@CS可以代表OA治疗的重要治疗策略。

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Maxing Yigan formula promotes cartilage regeneration by regulating chondrocyte autophagy in osteoarthritis.

Maxing Yigan formula (MYF) is a traditional Chinese medicine (TCM) prescription used for the treatment of OA for decades in China. However, the mechanism remains unknown. In this study, we developed a MYF-incorporated collagen sponge (MYF@CS) and investigated its cartilage regeneration effect and the underlying mechanism. In vitro experiments revealed that MYF significantly promoted cell viability, proliferation, and autophagy of OA chondrocytes. Furthermore, MYF@CS significantly enhanced chondrogenesis and cartilage regeneration, as assessed by macroscopic observation, the International Cartilage Repair Society (ICRS) visual histological score, and histological examination. Our findings suggest that MYF@CS could represent a significant therapeutic strategy for the treatment of OA.

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来源期刊

In Vitro Cellular & Developmental Biology. Animal 生物-发育生物学

CiteScore

3.70

自引率

4.80%

发文量

审稿时长

3 months

期刊介绍： In Vitro Cellular & Developmental Biology - Animal is a journal of the Society for In Vitro Biology (SIVB). Original manuscripts reporting results of research in cellular, molecular, and developmental biology that employ or are relevant to organs, tissue, tumors, and cells in vitro will be considered for publication. Topics covered include: Biotechnology; Cell and Tissue Models; Cell Growth/Differentiation/Apoptosis; Cellular Pathology/Virology; Cytokines/Growth Factors/Adhesion Factors; Establishment of Cell Lines; Signal Transduction; Stem Cells; Toxicology/Chemical Carcinogenesis; Product Applications.