日本一株罕见pcr -核糖型153引起的暴发性艰难梭菌感染1例。

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-12-21 DOI:10.1016/j.anaerobe.2024.102936

Daichi Yomogida, Suguru Hasegawa, Shiori Mizuta, Shinjiro Horikawa, Yoshinao Koshida, Koichiro Matsuda, Masahiko Nakamura, Hiroyasu Kaya, Akio Uchiyama, Mitsutoshi Senoh

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引用次数: 0

摘要

艰难梭菌感染（CDI），当产生毒素A，毒素B和CDT时，通常是严重的，可引起危及生命的暴发性感染，特别是在脆弱的患者中。本病例报告讨论了一名无病史的39岁女性，在抗生素治疗后发生严重CDI，导致致命的低血容量性休克。鉴定出一种罕见的难辨梭菌pcr -核糖型153菌株，毒素A，毒素B和CDT阳性。该病例强调了早期CDI诊断、谨慎使用抗生素和及时治疗的必要性，以防止休克和多器官衰竭等严重后果。

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Fulminant Clostridioides (Costridium) difficile infection caused by a rare strain of PCR-ribotype 153 in Japan: A case report.

Clostridioides (Clostridium) difficile (C. difficile) infection (CDI), often severe when producing toxin A, toxin B, and CDT, can cause life-threatening fulminant infections, especially in vulnerable patients. This case report discusses a 39-year-old woman with no medical history who developed severe CDI after antibiotic treatment, leading to fatal hypovolemic shock. A rare C. difficile PCR-ribotype 153 strain which is positive for toxin A, toxin B, and CDT was identified. This case emphasizes the need for early CDI diagnosis, cautious antibiotic use, and prompt treatment to prevent severe outcomes like shock and multiorgan failure.

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.