抑制磷酸二酯酶1和4可防止Peyronie病的肌成纤维细胞转化

IF 3.7 2区医学 Q1 UROLOGY & NEPHROLOGY

BJU International Pub Date : 2024-12-23 DOI:10.1111/bju.16631

Sophie L. Harding, Marcus M. Ilg, Stephen A. Bustin, David J. Ralph, Selim Cellek

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引用次数: 0

摘要

研究从佩氏病（PD）患者的白膜（TA）分离的成纤维细胞中表达哪些磷酸二酯酶（PDE）亚型，并测量PDE抑制剂在阻止这些成纤维细胞向纤维化肌成纤维细胞转化方面的效力。

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Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease

To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.

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来源期刊

BJU International 医学-泌尿学与肾脏学

CiteScore

9.10

自引率

4.40%

发文量

262

审稿时长

1 months

期刊介绍： BJUI is one of the most highly respected medical journals in the world, with a truly international range of published papers and appeal. Every issue gives invaluable practical information in the form of original articles, reviews, comments, surgical education articles, and translational science articles in the field of urology. BJUI employs topical sections, and is in full colour, making it easier to browse or search for something specific.