INWORKS和广岛/长崎白血病结果。

IF 2.3 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Dose-Response Pub Date : 2024-12-19 eCollection Date: 2024-10-01 DOI:10.1177/15593258241303476
Ken Robert Chaplin
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引用次数: 0

摘要

辐射效应研究基金会进行的广岛/长崎(H/N)研究没有显示低于200毫格瑞的急性剂量会增加白血病。相比之下,INWORKS对工人白血病的研究表明:“这项研究提供了强有力的证据,证明长期低剂量辐射暴露与白血病之间存在正相关。”INWORKS研究还声称,累积职业剂量低于100毫戈瑞时,白血病增加,不包括慢性淋巴细胞白血病。这与预期相反,H/N研究将显示比工人研究更严重的影响,因为剂量是急性的而不是慢性的,因为H/N研究包括的儿童比成人患辐射引起的白血病的比率更高。本文表明INWORKS白血病研究与H/N研究一致,在低剂量范围内白血病没有增加。此外,白血病的任何增加都局限于慢性髓系白血病,可能是高辐射剂量率或化学物质造成的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
INWORKS and Hiroshima/Nagasaki Leukaemia Results.

The Hiroshima/Nagasaki (H/N) studies by the Radiation Effect Research Foundation have not shown increased leukaemia for acute doses below 200 milli-gray (mGy). By contrast the INWORKS study of leukaemia in workers stated: "This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukemia". The INWORKS study also claimed increased leukaemia, not including Chronic Lymphocytic Leukaemia, at cumulative occupational doses of less than 100 mGy. This is contrary to the expectation that the H/N studies would show more severe effects than the worker study because the doses were acute instead of chronic and because the H/N studies included children who had higher rates of radiation induced leukaemia than adults. This paper shows that the INWORKS leukaemia study is consistent with the H/N studies in showing no increase in leukaemia in the low-dose range. In addition, any increase in leukaemia is confined to Chronic Myeloid Leukaemia, possibly from high radiation dose-rates or chemicals.

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来源期刊
Dose-Response
Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
4.90
自引率
4.00%
发文量
140
审稿时长
>12 weeks
期刊介绍: Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.
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