中性粒细胞百分比与白蛋白比率与中风的关系：来自NHANES 1999-2020的证据。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-12-22 DOI:10.1002/brb3.70192

Shuying Xu, Yiyan Sun, Siyao Zhang, Yongjun Peng, Dechun Dai, Leiyong Zhao

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引用次数: 0

摘要

目的：探讨中性粒细胞百分比-白蛋白比（NPAR）与脑卒中的关系，为临床脑卒中的预防及预后提供参考。方法：纳入全国健康与营养调查（NHANES）的56566名参与者，采用logistic回归和限制性三次样条分析NPAR与脑卒中的关系。在识别非线性关系后，利用递归算法和两阶段线性回归模型计算拐点。分层分析和相互作用测试检验了不同人群之间的差异。结果：调整混杂因素后，NPAR与卒中呈正相关（OR: 1.09, 95% CI: 1.05-1.12）。限制三次样条分析显示出非线性趋势。超过拐点后，随着NPAR水平的升高，脑卒中发病率的上升趋势开始放缓。这种关系在男性中是非线性的，而在女性中是线性的。结论：本研究揭示了NPAR与脑卒中之间的非线性正相关，NPAR越高，脑卒中风险越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Relationship of Neutrophil Percentage-to-Albumin Ratio With Stroke: Evidence From NHANES 1999–2020

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Relationship of Neutrophil Percentage-to-Albumin Ratio With Stroke: Evidence From NHANES 1999–2020

Objective

The objective of this research is to examine the association between neutrophil percentage-to-albumin ratio (NPAR) and stroke, providing a reference for the prevention and prognosis of clinical stroke.

Method

The study included 56,566 participants from the National Health and Nutrition Examination Survey (NHANES) to explore the association between NPAR and stroke using logistic regression and restricted cubic splines. Upon identifying the nonlinear relationship, inflection points were calculated using recursive algorithms and two-stage linear regression models. Stratified analyses and interaction tests examined variations across population groups.

Results

After adjusting for confounders, NPAR was positively associated with stroke (OR: 1.09, 95% CI: 1.05–1.12). Restricted cubic spline analysis indicated a nonlinear trend. Beyond the inflection point, the increasing trend of stroke incidence with higher NPAR levels began to slow down. This relationship remained nonlinear in males but was linear in females.

Conclusion

This study revealed a nonlinear positive association between NPAR and stroke, with higher NPAR increasing the risk of stroke.

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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