钐掺杂羟基磷灰石纳米颗粒的发光特性及对SH-SY5Y神经母细胞瘤细胞的毒性评价。

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2024-12-02 eCollection Date: 2024-12-17 DOI:10.1021/acsomega.4c08654

Stephanie Enríquez, Sarah Briceño, Lenin Ramirez-Cando, Alexis Debut, Luis J Borrero-González, Gema González

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引用次数: 0

摘要

掺钐纳米羟基磷灰石是一种具有神经再生活性和生物成像功能的生物材料。在这部作品中，Sm/HAp；采用水热法合成(Ca10-x Sm x (PO4)6(OH)2)(0≤x≤1)，并在200 ~ 800℃进行热处理。采用透射电子显微镜、能量色散x射线光谱、傅里叶变换红外光谱、x射线衍射、拉曼光谱和发光光谱对样品进行了表征。结果证实Sm3+离子成功整合到羟基磷灰石中。我们的研究结果揭示了Sm3+含量和热处理对发射性能的影响，在800°C热处理时获得了Sm = 0.05的最大发射。SH-SY5Y神经母细胞瘤细胞活力研究显示Sm3+浓度和颗粒大小依赖性反应。本研究强调Sm/HAp在SH-SY5Y神经母细胞瘤细胞中的光学和细胞活力，使其适合作为激活细胞和神经元再生过程的药物进行进一步研究。

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Luminescence Properties of Samarium-Doped Hydroxyapatite Nanoparticles and Cytotoxicity Assessment on SH-SY5Y Neuroblastoma Cells.

Samarium-doped nanohydroxyapatite is a biomaterial with nerve regeneration activity and bioimaging. In this work, Sm/HAp; (Ca_10-x Sm _x (PO₄)₆(OH)₂) (0 ≤ x ≤ 1) was synthesized using the hydrothermal method and thermally treated from 200 to 800 °C. The samples were characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, and luminescence spectroscopy. The results confirmed the successful integration of Sm³⁺ ions into the hydroxyapatite. Our findings revealed the influence of the Sm³⁺ content and thermal treatment on the emission properties, obtaining a maximum emission at Sm = 0.05 thermally treated at 800 °C. The SH-SY5Y neuroblastoma cell viability study revealed a Sm³⁺ concentration-and particle size-dependent response. This research emphasizes the optical and cell viability of Sm/HAp in SH-SY5Y neuroblastoma cells, making them suitable for further research as agents that activate regenerative processes in cells and neurons.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.