利用n -羟胺活性酯合成奥司他韦酰胺衍生物

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-02-03 DOI:10.1002/ejoc.202401139

Barbora Zahradníková , Zuzana Mravíková , Viktória Némethová , Petra Polnišerová , Vladimír Frecer , Mária Mečiarová , Radovan Šebesta

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引用次数: 0

摘要

药物的功能化和衍生化是制备新的潜在活性化合物的必要条件。这项工作表明，从羧酸奥司他韦衍生的活性酯可以成为获取奥司他韦各种酰胺衍生物的有用合成工具。以羧酸奥司他韦为原料直接合成了6种羟胺活性酯，并评价了它们在酰胺类衍生物制备中的应用。琥珀酰亚胺酯5e在制备和合成奥司他韦衍生物方面效率最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Utilizing N‐Hydroxylamine‐Based Active Esters for the Synthesis of Oseltamivir Amide Derivatives

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Utilizing N‐Hydroxylamine‐Based Active Esters for the Synthesis of Oseltamivir Amide Derivatives

Functionalizing and derivatizing pharmaceuticals are essential for preparing new potentially active compounds. This work shows how active esters derived from oseltamivir carboxylate can be useful synthetic tools for accessing various amide derivatives of oseltamivir. Six hydroxylamine active esters were synthesized directly from oseltamivir carboxylate, and their utility in preparing amide derivatives was evaluated. Succinimide ester 5 e was the most efficient in terms of its preparation and in synthesizing oseltamivir derivatives.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.