N-（4-羟基苯基）-磺酰胺与磺酰肼直接磺化的电化学方法

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-02-03 DOI:10.1002/ejoc.202401126

Yanan Li , Lin Li , Feiyang Li , Shuaihu Hu , Rui Zhu , Jianan Sun

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引用次数: 0

摘要

成功地开发了一种由N-（4-羟基苯基）-磺酰胺和磺酰肼合成磺基苯酚衍生物的简便电化学策略。该方案不含金属和氧化剂，适用于芳香族、杂芳香族和脂肪族试剂，在温和的条件下以中高收率获得相应的磺化产物。进行了克级实验和体外抗菌试验，以证明该方法的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An Electrochemical Method for the Direct Sulfonylation of N‐(4‐hydroxyphenyl)‐sulfonamides with Sulfonyl Hydrazides

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An Electrochemical Method for the Direct Sulfonylation of N‐(4‐hydroxyphenyl)‐sulfonamides with Sulfonyl Hydrazides

A facile electrochemical strategy for the synthesis of sulfonylphenol derivatives from N‐(4‐hydroxyphenyl)‐sulfonamides with sulfonyl hydrazides has been successfully developed. This metal‐ and oxidant‐free protocol is suitable for aromatic, heteroaromatic and aliphatic reagents to afford the corresponding sulfonylated products in moderate to high yields under mild conditions. A gram‐scale experiment and an in vitro antibacterial assay were conducted to demonstrate the potential utility of this approach.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.