n -亚硝基胺和有机卤化物对苯乙烯的可见光诱导自由基碳氧化反应

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-12-23 DOI:10.1021/acs.joc.4c02193

Jinping Lan, Xiaolong Li, Mengyu Xu, Bin Zhang, Jin Luo, Yuan Zhou, Tao Wang

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引用次数: 0

摘要

研究了苯乙烯与1-亚硝基吡咯烷和有机卤化物的可见光诱导自由基碳氧化反应。在温和的条件下，在没有过渡金属和光催化剂的情况下，反应进行得很顺利，以中等到良好的产率生产出广泛的功能化肟。机理研究表明，该反应涉及亲核α-氨基烷基自由基的生成和卤素原子与有机卤化物的转移（XAT）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Induced Radical Carbon Oximation of Styrenes Using N-Nitrosoamine and Organic Halides

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Visible-Light-Induced Radical Carbon Oximation of Styrenes Using N-Nitrosoamine and Organic Halides

An efficient visible-light-induced radical carbon oximation of styrenes with 1-nitrosopyrrolidine and organic halides is developed. The reaction proceeds smoothly in the absence of a transition metal and a photocatalyst under mild conditions, producing a wide range of functionalized oximes in moderate to good yields. Mechanistic studies reveal that the reaction involves the generation of nucleophilic α-amino alkyl radicals and subsequent halogen atom transfer (XAT) with organic halides.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.