铜和DMAP接力催化末端炔、邻苯胺和醇的三组分偶联模块化合成2-烷氧基喹啉

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-12-23 DOI:10.1002/adsc.202401293

haixia Li, Yang Gao, xiongwei Zhong, Yanping Huo, Xianwei Li, Qian Chen

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引用次数: 0

摘要

采用铜和DMAP接力催化的方法，实现了末端炔、蒽酚和醇的三组分偶联模块化合成2-烷氧基喹啉的策略。在这个过程中，形成了一种新的喹啉吡啶盐，并作为2-烷氧基喹啉形成的关键中间体。该反应的底物范围很广，每个反应伙伴都可以产生多样化的2-烷氧基喹啉产品，收率普遍较高。

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Copper and DMAP relay-catalyzed three-component coupling of terminal alkynes, anthranils and alcohols for the modular synthesis of 2-alkoxy quinolines

A copper and DMAP relay-catalyzed strategy has been achieved for the modular synthesis of 2-alkoxy quinolines from a three-component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2-alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2-alkoxy quinoline products in generally good yields.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.