调整基于纳米载体的药物递送的超分子聚集体的形态

IF 3.5 3区工程技术 Q2 ENGINEERING, CHEMICAL

AIChE Journal Pub Date : 2024-12-23 DOI:10.1002/aic.18717

Xiongtao Ji, Na Wang, Jingkang Wang, Yunhai Huang, Ting Wang, Xin Huang, Hongxun Hao

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引用次数: 0

摘要

由于其独特的药物传递模式和特异性治疗，纳米制剂在生物医学应用和治疗许多疾病方面具有重要意义。然而，通过额外的载体或治疗药物的结构修饰来构建纳米制剂的传统方法可能是繁琐的或低负载效率。本文详细研究了治疗药物的超分子组装过程的动力学、可达途径和最终结果。研究发现，头孢定（CEP）的超分子聚集体经历了从各向异性纳米纤维（EtOH）到各向同性球形纳米颗粒（H2O）的形态转变，类似于“植物生根、发芽、开花、结果”。此外，组装动力学结果揭示了在H2O中成核延伸和在EtOH中表面催化的二次成核的组装途径。在这项工作中提出的方法有潜力用于有效地设计特定的纳米制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tuning the morphology of supramolecular aggregates for nanocarrier‐based drug delivery

Due to the unique drug delivery mode and specific therapy, nano‐formulations are of interest for biomedical applications and treating many diseases. However, traditional method of nano‐formulation construction via additional carriers or structural modifications of therapeutic drugs might be cumbersome or low loading‐efficient. Herein, the kinetics, accessible pathways, and final outcomes of supramolecular assembly processes of therapeutic drugs are investigated in detail. It was found that the supramolecular aggregates of cephradine (CEP) undergoes a morphological transformation from anisotropic nanofiber (EtOH) to isotropic spherical nanoparticle (H2O), similar to “plants took root, sprouted, blossomed and bore fruit.” Moreover, the assembly kinetics results reveal the assembly pathways of nucleation elongation in H2O and surface‐catalyzed secondary nucleation in EtOH. The method presented in this work has the potential to be used for efficiently designing specific nano‐formulations.

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来源期刊

AIChE Journal 工程技术-工程：化工

CiteScore

7.10

自引率

10.80%

发文量

411

审稿时长

3.6 months

期刊介绍： The AIChE Journal is the premier research monthly in chemical engineering and related fields. This peer-reviewed and broad-based journal reports on the most important and latest technological advances in core areas of chemical engineering as well as in other relevant engineering disciplines. To keep abreast with the progressive outlook of the profession, the Journal has been expanding the scope of its editorial contents to include such fast developing areas as biotechnology, electrochemical engineering, and environmental engineering. The AIChE Journal is indeed the global communications vehicle for the world-renowned researchers to exchange top-notch research findings with one another. Subscribing to the AIChE Journal is like having immediate access to nine topical journals in the field. Articles are categorized according to the following topical areas: Biomolecular Engineering, Bioengineering, Biochemicals, Biofuels, and Food Inorganic Materials: Synthesis and Processing Particle Technology and Fluidization Process Systems Engineering Reaction Engineering, Kinetics and Catalysis Separations: Materials, Devices and Processes Soft Materials: Synthesis, Processing and Products Thermodynamics and Molecular-Scale Phenomena Transport Phenomena and Fluid Mechanics.