糖尿病性心肌病的心肌纤维化：机制、意义和治疗前景。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-12-18 DOI:10.1016/j.cpcardiol.2024.102976

Clara Elisabeth Schmidt, Hans Dietrich Müller

引用次数: 0

摘要

糖尿病性心肌病（DCM）是一种独特的心脏病形式，其特征是心肌结构和功能改变，发生在没有其他心脏疾病的情况下。本文深入探讨了DCM中心肌纤维化的病理生理机制，强调了成纤维细胞转分化为肌成纤维细胞的关键作用。我们研究了高血糖、免疫细胞激活和神经体液信号通路之间的相互作用，特别关注转化生长因子-β (TGF-β)信号级联及其对胶原沉积和心功能障碍的贡献。尽管在理解DCM的细胞和分子机制方面取得了重大进展，但在阐明成纤维细胞激活的精确调控网络以及microrna在这些过程中的作用方面仍然存在关键空白。通过对现有知识的全面概述，本综述旨在确定潜在的治疗靶点，以减轻心肌纤维化和改善糖尿病患者的临床结果。最终，解决这些空白将为新的治疗策略铺平道路，这些策略可以增强心脏功能并减轻糖尿病心肌病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.