QAS/PLA微/纳米复合材料制备生物降解抗菌编织结构包芯纱。

Jun Xu, Xingyu Zhao, Zhenzhen Lei, Huimin Jia, Haolong He, Genghao Gong, Jing Wang, Tiegang Wang
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引用次数: 0

摘要

医用抗菌纺织品在解决细菌感染问题上发挥着至关重要的作用。传统的手术缝合线由于细菌引起的伤口感染和缝合线强度差造成的破损和疤痕,面临着巨大的挑战。因此,迫切需要一种具有广泛临床适用性的新型抗菌、高强度缝线制备策略。采用共轭静电纺丝技术与编织工艺相结合,制备了具有良好抗菌性能和力学性能的可生物降解季铵盐(QAS)/聚乳酸(PLA)包芯纱。抗菌试验结果表明,添加0.3 wt% QAS抗菌剂的聚乳酸微纳纤维包芯纱综合性能最佳。对大肠杆菌和金黄色葡萄球菌的抑菌率分别为94.49%和94.00%,可有效解决细菌引起的伤口感染问题。此外,我们使用钻石编织结构来解决传统缝合强度差和脆弱的问题。30°和45°编织角度能有效提高纱线的力学性能,断裂强度也符合行业标准。本研究认为,可降解QAS/PLA微/纳米纤维包芯纱具有优异的抗菌性能和力学性能,在医疗防护领域具有广阔的应用前景。这为新型抗菌手术缝合线的研究提供了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation of biodegradable, antibacterial core-spun yarns with braided structures using QAS/PLA micro/nanocomposites.

Medical antibacterial textiles play a vital role in tackling the issue of bacterial infection. Traditional surgical sutures face significant challenges due to wound infection caused by bacteria and breakage and scars caused by poor suture strength. Therefore, a new antibacterial and high-strength suture preparation strategy with wide clinical applicability was highly desired. In this study, a biodegradable quaternary ammonium salt (QAS)/polylactic acid (PLA) core-spun yarn with excellent antibacterial and mechanical properties was prepared by conjugated electrospinning technology combined with the braiding process. The antibacterial test results revealed the best overall performance of the PLA micro/nanofiber core-spun yarn with 0.3 wt% QAS antibacterial agent. The antibacterial rate against Escherichia coli and Staphylococcus aureus was 94.49% and 94.00%, respectively, which could effectively solve the problem of wound infection caused by bacteria. In addition, we used the diamond-braided structure to address the poor strength and fragility of the traditional suture strength. The braiding angle of 30° and 45° could effectively enhance the mechanical properties of the yarn, and the breaking strength was also in line with the industry standard. The study proposed that the degradable QAS/PLA micro/nanofiber core-spun yarn, due to its excellent antibacterial and mechanical properties, could find application in medical protection. This provided a new avenue for research into new antibacterial surgical sutures.

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